Nature Search

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

A deep mutational scanning approach identifies mutations that allow subvariants of the prevalent JN.1 SARS-CoV-2 strain to evade Omicron-induced neutralizing antibodies, indicating a need for careful monitoring of this lineage in vaccine development.

Fanchong Jian
Jing Wang
Yunlong Cao
ResearchOpen Access07 Nov 2024
Nature

Volume: 637, P: 921-929
Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion

Differential intracellular regulation of mTOR activity in non-ipRGCs and ipRGCs contributes to their distinct susceptibility to I/R injury and this can be regulated by rapamycin under specific light conditions.

Meizhen Zhu
Yuqing Wu
Yanli Ran
ResearchOpen Access11 Jun 2025
Communications Biology

Volume: 8, P: 1-14
The role of transposon inverted repeats in balancing drought tolerance and yield-related traits in maize

Transposon-associated inverted repeats play a role in drought resistance and yield-related traits in maize.

Xiaopeng Sun
Yanli Xiang
Mingqiu Dai
Research13 Oct 2022
Nature Biotechnology

Volume: 41, P: 120-127
A graph-based genome and pan-genome variation of the model plant Setaria

Setaria pan-genome constructed using genome assemblies of 110 representative accessions and variation analyses provides insights into foxtail millet domestication and the genetic basis for crop improvement.

Qiang He
Sha Tang
Xianmin Diao
ResearchOpen Access08 Jun 2023
Nature Genetics

Volume: 55, P: 1232-1242
Type-specific dendritic integration in mouse retinal ganglion cells

Neurons compute by integrating synaptic inputs across their dendritic arbor. Here, the authors show that distinct cell-types of mouse retinal ganglion cells that receive similar excitatory inputs have different biophysical mechanisms of input integration to generate their unique response tuning.

Yanli Ran
Ziwei Huang
Thomas Euler
ResearchOpen Access30 Apr 2020
Nature Communications

Volume: 11, P: 1-15
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding ___domain can cause immune evasion and maintain sufficient ACE2-binding capability.

Yunlong Cao
Fanchong Jian
Xiaoliang Sunney Xie
ResearchOpen Access19 Dec 2022
Nature

Volume: 614, P: 521-529
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multiple updated boosters.

Ayijiang Yisimayi
Weiliang Song
Yunlong Cao
ResearchOpen Access22 Nov 2023
Nature

Volume: 625, P: 148-156
SUMOylation of TARBP2 regulates miRNA/siRNA efficiency

As part of the miRNA-generating machinery, TARBP2 stabilizes the RNA-induced silencing complex (RISC) loading complex (RLC). Here, Chen et al.show that sumoylation of TARBP2 regulates RNAi efficiency by increasing precursor miRNAs loaded on RLC.

Cheng Chen
Changhong Zhu
Jianxiu Yu
ResearchOpen Access19 Nov 2015
Nature Communications

Volume: 6, P: 1-15
Hypoxia regulates overall mRNA homeostasis by inducing Met¹-linked linear ubiquitination of AGO2 in cancer cells

Met¹-linked linear ubiquitination (M¹-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M¹-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA targets.

Hailong Zhang
Xian Zhao
Jianxiu Yu
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-20
Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina

Motion vision is critical for survival. Here the authors show that motion detection occurs already in bipolar cells of the mouse retina, which may contribute to motion processing throughout the visual system.

Sarah Strauss
Maria M. Korympidou
Anna L. Vlasits
ResearchOpen Access26 Sept 2022
Nature Communications

Volume: 13, P: 1-18
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Chromodomains in chromatin-associated proteins act as ‘readers’ of methylated lysines within histones. Structural and computational design led to the identification of UNC3866, a potent, cell-active peptide-based inhibitor of the methyllysine reading functions of CBX and CDY chromodomains.

Jacob I Stuckey
Bradley M Dickson
Stephen V Frye
Research25 Jan 2016
Nature Chemical Biology

Volume: 12, P: 180-187
Neural circuits in the mouse retina support color vision in the upper visual field

Mice are able to discriminate colors, at least in the upper visual field. Here, the authors provide a comprehensive characterization of retinal circuits underlying this behavior.

Klaudia P. Szatko
Maria M. Korympidou
Katrin Franke
ResearchOpen Access13 Jul 2020
Nature Communications

Volume: 11, P: 1-14
Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma

Lian Li
Junya Li
Jianxiu Yu
Research13 Dec 2024
Cell Death & Differentiation

P: 1-21
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5

Zhe Chen
Leilei Feng
Qi Jin
ResearchOpen Access13 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-8
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Senolytic FOXO4-DRI selectively eliminates senescent fibroblasts by inducing nuclear exclusion of p53 phosphorylation, highlighting the role of the senescent microenvironment in keloid overgrowth and relapse.

Yu-Xiang Kong
Zhi-Shuai Li
Li Yan
ResearchOpen Access24 Feb 2025
Communications Biology

Volume: 8, P: 1-13
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis

Hailong Zhang
Yanli Wang
Jianxiu Yu
ResearchOpen Access10 Oct 2018
Oncogene

Volume: 38, P: 1410-1431
Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning

Xueli Zhang
Yanli Tian
Chongzhao Ran
ResearchOpen Access13 Aug 2015
Scientific Reports

Volume: 5, P: 1-14
Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

Jian Yang
Yuqi Guo
Xin Li
Research11 Feb 2019
Oncogene

Volume: 38, P: 4700-4714
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression

Yanmin Guo
Jianfeng He
Jianxiu Yu
Research03 Oct 2022
Oncogene

Volume: 41, P: 4877-4892
Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system

Rihong Guo
Yongjie Wan
Yanli Zhang
ResearchOpen Access15 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation

Jiayu Fang
Yuqin Zhang
Jian Huang
Research10 Feb 2023
Oncogene

Volume: 42, P: 1058-1071
A bottom-up model of functional outcome in schizophrenia

Hongge Luo
Yanli Zhao
Shuping Tan
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-10

Search

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion

The role of transposon inverted repeats in balancing drought tolerance and yield-related traits in maize

A graph-based genome and pan-genome variation of the model plant Setaria

Type-specific dendritic integration in mouse retinal ganglion cells

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

SUMOylation of TARBP2 regulates miRNA/siRNA efficiency

Hypoxia regulates overall mRNA homeostasis by inducing Met¹-linked linear ubiquitination of AGO2 in cancer cells

Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Neural circuits in the mouse retina support color vision in the upper visual field

Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma

A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

The United States COVID-19 Forecast Hub dataset

Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis

Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression

Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system

Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation

A bottom-up model of functional outcome in schizophrenia

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