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Organic electrode materials are promising candidates for rechargeable Al-ion batteries but face the capacity ceiling due to limited active sites and low electron transfer number. Here, authors develop a tetraalkynylporphyrin cathode with 12-electron transfer to achieve high energy Al-organic batteries.

Here the authors show structures of the vesicular acetylcholine transporter in its apo state and in complex with the substrate acetylcholine and the inhibitor vesamicol, providing insights into substrate recognition, proton coupling and conformational transition mechanisms.

In a randomized controlled trial involving patients with heart failure with reduced ejection fraction, treatment with Qiliqiangxin, a traditional Chinese medicine derived from 11 types of plants, decreased the incidence of cardiac events, as compared to placebo.

Differential intracellular regulation of mTOR activity in non-ipRGCs and ipRGCs contributes to their distinct susceptibility to I/R injury and this can be regulated by rapamycin under specific light conditions.

Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2_Nme alone and in complex with Cas9.

Extrusion bioprinting can be used to produce living materials but controlling cell microenvironments is challenging. Here, the authors use a type of core-shell microgel ink that decouples cell culture from material processing to produce functional materials with a range of potential applications.

Stabilizing non-trivial magnetic spin textures at room temperature remains challenging. Here, the authors propose introducing magnetic atoms into the van der Waals gap of 2D magnets Fe₃GaTe₂ to stabilize the magnetic spin textures beyond skyrmion.

The sperm flagellum is composed of tubulin-based microtubules and is critical for sperm motility and thus male fertility. Here, the authors show that STYXL1 regulates CCT complex-facilitated tubulin folding and is essential for sperm flagella formation.

Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.

Polymerizations in living systems can effectively regulate cell functions and behaviors, but their uses have been hindered by the existence of complicated intracorporal interferences, the needs of high concentration of monomers and extra stimulates. Here, the authors address these issues by developing a nanocompartment-confined strategy to achieve broad-spectrum polymerizations in living systems.

CaV1.2 is crucial in cardiac, vascular and neuronal function, serving as a target for many drugs. Here, authors identify the binding site of herb-derived drug tetrandrine, and explore inhibitory mechanism of L/T-type selective DHP drug benidipine.

The Ca_V2.3 channel is involved in synaptic plasticity and neurological disorders. Here, authors resolve the human Ca_V2.3 structure to explore functional heterogeneity of VSDs and elucidated the closed- and open-state inactivation mechanisms of the channel.

Setaria pan-genome constructed using genome assemblies of 110 representative accessions and variation analyses provides insights into foxtail millet domestication and the genetic basis for crop improvement.

To trace the sources of Black Carbon being transported into the Tibetan Plateau is crucial for guiding an effective mitigation strategy. Here the authors utilized the adjoint of the Goddard Earth Observing System-Chem model and find that international trade aggravates the BC pollution over the HTP glacier regions and may cause significant climate change.

PTEN is a tumour suppressor that inhibits activation of the phosphatidylinositol 3-kinase pathway. These authors show that PTEN is SUMOylated on two lysine residues and that this modification is required for binding to acidic phospholipids and blocking tumour formation in mice.

Materials with room temperature phosphorescence have potential in a range of applications, but preparing the systems can still be challenging. Here, the authors report an intrinsically polymeric room temperature phosphorescent material, applied in crack detection.

Na_V1.3 is involved in neuronal development, hormone secretion and pain perception. Here, the authors elucidate the molecular mechanism for modulation of Na_V1.3 by a site-2 neurotoxin bulleyaconitine A and a subtype selective antagonist ICA121431.

Cryo-EM structures of the human pentameric glycosylphosphatidylinositol transamidase (GPIT) complex reveal its subunit assembly and its catalytic and GPI-binding sites.

SOS1 is a unique electroneutral Na⁺ /H⁺ antiporter at the plasma membrane of higher plants and plays a central role in resisting salt stress. Here, the authors report the structures of SOS1 in occluded state, identify the key autoinhibitory elements, and elucidate their molecular mechanism.

Gene editing induces paternal haploid plants in hexaploid wheat.

Crops with broad-spectrum resistance to multiple diseases are highly desirable in agricultural production. This study reports a natural gene variant that produces a proteasome maturation factor and improves rice resistance to four notorious pathogens.

Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.

Analysis of 11 flatfish genomes indicates that Pleuronectoidei and Psettodoidei are not a monophyletic group. Genomic and transcriptomic data suggest that the WNT and RA pathways played a role in the evolution of the specialized body of flatfish.

Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.

As part of the miRNA-generating machinery, TARBP2 stabilizes the RNA-induced silencing complex (RISC) loading complex (RLC). Here, Chen et al.show that sumoylation of TARBP2 regulates RNAi efficiency by increasing precursor miRNAs loaded on RLC.

Successful identification of mouse embryonic pre-haematopoietic stem cells at single-cell resolution.

Excitatory amino acid transporter 2 (EAAT2) mediates glutamate uptake in the synapse. Here, authors report cryo-EM structures of the human EAAT2 in complexes with glutamate or selective inhibitor WAY-213613, revealing important insights into substrate recognition and selective inhibition.

T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.

The authors report the structures of glutamate-gated kainate receptors in complex with NETO2 in both the resting and the desensitized states and reveal how kainate receptors in the brain are regulated by NETO2.

Ye and colleagues show that an oncolytic virus that delivers tumor-irrelevant bystander T cell epitopes to tumor cells can exploit the abundant population of bystander T cells in the tumor for anti-tumor immunity and potentiate cancer immunotherapy.

While hydrogels find applications in wearable sensors and electronic skins, they are prone to fatigue fractures upon deformation cycling. Xiong et al. report the synthesis of conductive polymerizable rotaxane hydrogels, exhibiting large fatigue resistance, for 3D printable flexible sensors.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genes