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Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activating this pathway rescues CREB-dependent memory in aged worms.

This study employs time-lapse single-nucleus RNA sequencing in Arabidopsis seedlings, revealing distinct circadian rhythms in specific cell types and identifying ABF1 as a regulator that shortens the circadian period.

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

The quasi-two-dimensional antiferromagnet Co_1/3NbS₂ was recently reported to have a significant anomalous Hall effect. However, its controversial spin configuration has presented challenges in understanding the physical mechanism behind the AHE. Here, through an array of experimental probes, Gu, Peng and coauthors verify an intrinsic k-space Berry curvature as origin of the spontaneous Hall effect, and elucidate the ___domain-related magnetic reversal behaviours.

This study provides a de novo resequencing of 802 Camellia accessions and a genome-wide variation map. Genome-wide association study (GWAS) and metabolite GWAS identify genes responsible for crucial agronomic and flavor traits.

Achieving CO oxidation at room temperature is significant for gas purification but remains challenging to perform. Here, the authors report design of graphene-isolated Pt from cobalt-nickel nanoparticles for efficiently catalytic CO oxidation in an oxygen-rich atmosphere.

Middle-aged obesity, marked by excessive fat accumulation, is closely linked to DNA damage. Here, the authors show that the DNA repair enzyme Eepd1, primarily expressed in adipose tissue, in its myristoylated form, promotes lipolysis and thermogenesis by activating PKA to combat obesity.

Solid-phase synthesis strategy is promising for fabricating desired complex metal nanoparticles on supports. Here, the authors synthesize CoFe@FeOx core-shell nanoparticles as the separator coatings via precise solid-phase method which effectively regulates polysulfides for lithium/ sodium-sulfur batteries.

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

Single-nucleus transcriptomes uncover cell type-specific gene reprogramming in response to nod factors in Medicago, including a defence response at 30 min, which largely returned to normal at 6 h. The results reveal that MtFER interacts with LYK3 and regulates rhizobial symbiosis.

PXR regulates glycolipid metabolism, but the role of intestinal PXR in metabolic diseases remains unknown. Here, the authors show the intestinal-selective PXR activation regulates B3galt5 expression and maintains metabolic homeostasis via regulating the intestinal mucus barrier.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

Designing photocatalysts to enhance the efficiency of non-oxidative coupling of methane is a challenging task. Here, the authors report that the anatase TiO₂ with exposed {101} facets and Pd co-catalyst enables efficient and selective methane coupling to ethane via a heterogeneous-homogeneous hybrid reaction pathway.

By overcoming the limited solubility of other lighter components in aluminum using high pressure and high temperature, a low-density, high specific strength, and single-phase aluminum-based complex concentrated alloy is developed.

Here the authors find that the mRNA of GYS2, the liver-specific glycogen synthase, is a substrate of METTL3 and IGF2BP2 and that m6A-mediated regulation of Gys2 mRNA is critical for the maintenance of liver glycogenesis in mammals during growth, such as mice and rats.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This ___domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

An improved watermelon reference genome and whole-genome resequencing of 414 cultivated and wild accessions provide insights into fruit quality traits and dessert watermelon evolution.

The fabrication of n- and p-type semiconducting channels based on the same layered material would simplify the implementation of 2D electronics. Here, the authors report a spatially selective doping method for the synthesis of wafer-scale p- and n-type 2H-MoTe₂ thin films, and their application for the realization of complementary 2D transistor and inverter arrays.

The isolation of graphene lead to a surge of interest in van der Waals materials, with more recent isolation of individual layers of transition metal chalcogenides, and various magnetic van der Waals materials. For many of these materials, controlled growth of one-dimensional systems, nanoribbons for example, have been demonstrated. Here, Lu et al add to this CrCl3, a van der Waals magnetic material, growing one-dimensional wires and observing their magnetic ordering via scanning tunneling microscopy.

Solving component homogeneity and sulfur instability of metal sulfides is crucial for photocatalytic overall water splitting. Here, the authors develop a distortion evoked cation site oxygen doping to create electronegativity differences between adjacent atom and enhance photocatalytic activity

Broadband terahertz (THz) pulses are generated from a laser filament with a near-infrared laser at the fundamental frequency and its second harmonic. The azimuthal angle and ellipticity of the THz pulses are arbitrarily controlled by the two lasers.

Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment.

N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade.

Marine ecosystems are dominated by microbial communities. Inspired by the photoelectric conversion feature of the marine ecosystems, the authors design a four-species microbial community to mimic primary producer, primary degrader, and ultimate consumers, and show its ability to convert light into electricity for over one month.

Little is known about viral communities in deep-sea seamounts. In this study, the authors performed metagenomic and virome analysis from sediments in the western Pacific Ocean and characterize the diversity, distribution and potential ecological roles of viruses in deep-sea seamount sediments.

Mast cells have been shown to be involved with rheumatoid arthritis, but the mechanisms are not clear. Here using mouse models and making association with human patients, the authors show mast cells have an important function in the pathogenesis of rheumatoid arthritis, involving regulation of T cell responses and release of mast cell mediators.

Recent estimates of sugar-sweetened beverages (SSBs) intake are generally unavailable. Here the authors show a global SSBs intake of 2.7 servings/week in 2018 in adults (range: 0.7 South Asia, 7.8 Latin America/Caribbean); intakes were higher among males, younger, more educated, and urban adults.

The large low-shear-velocity anomalies in the deep lower mantle below 2300 km depth may relate to H₂O-induced ferrous iron stability in bridgmanite, according to laser-heated diamond anvil cell experiments.

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

Zheng et al. generate and utilize a biobank of colorectal cancer PDOs to find that high LGR4 is linked to chemoresistance. They develop a monoclonal antibody against LGR4 that activates ferroptosis and is therapeutically beneficial.

The conserved BAR ___domain protein FAM92A1 is known to induce membrane curvature. Here, the authors report the crystal structure of its BAR ___domain and perform an extensive characterization of the brain and behavior of FAM92A1 knockout mice.

An analysis based on data from the Global Dietary Database shows mean animal-sourced food intakes among children and adolescents increased modestly from 1990 to two portions per day in 2018, but remain low in sub-Saharan Africa, India and Bangladesh.