Nature Search

Editorial Expression of Concern to: The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Wan-Li Ge
Qun Chen
Kui-Rong Jiang
Amendments and CorrectionsOpen Access23 May 2025
Cell Death & Disease

Volume: 16, P: 1
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers

The early pathophysiology of Parkinson’s disease is not well understood. Here the authors perform large-scale proteomic analyses of incident Parkinson’s disease to reveal pathophysiological insights and potential biomarkers, providing targets for early disease detection and guiding targeted therapeutic strategies.

Yi-Han Gan
Ling-Zhi Ma
Jin-Tai Yu
Research20 Feb 2025
Nature Aging

Volume: 5, P: 642-657
SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

While SNAP25 is critical for neural electrical communication, its cardiac role is unknown. Here the authors show that it governs atrial electrical stability by directing Kv1.5 channel trafficking, with therapeutic implications for atrial fibrillation.

Xuling Su
Beihua Shao
Yi-Han Chen
ResearchOpen Access19 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Endothelial deletion of PTBP1 disrupts ventricular chamber development

Alternative splicing crucially affects various biological processes, however, its function in heart development is largely unknown. Here, the authors show an essential role of alternative splicing factor PTBP1 in ventricular chamber development.

Hongyu Liu
Ran Duan
Yi-Han Chen
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

Lingyu Meng
Cuicui Liu
Zuoren Yu
ResearchOpen Access03 Jan 2017
Nature Communications

Volume: 8, P: 1-10
CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

Phosphorylation catalyzed by kinases is a key event in signaling pathways involved in cardiomyocyte hypertrophy. Here the authors show that the kinase CLK4 ameliorates cardiac hypertrophy by phosphorylating NEXN.

Jian Huang
Luxin Wang
Yi-Han Chen
ResearchOpen Access30 Jul 2022
Nature Communications

Volume: 13, P: 1-13
SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment ___domain

Identification of pathways that drive proper cardiac function is key to prevention and treatment of heart disease. Here the authors describe a novel pathway that regulates cardiomyocyte survival, which involves a sorting protein, SNX13, and its binding partner, ARC, a multifunctional inhibitor of apoptosis.

Jun Li
Changming Li
Yi-Han Chen
Research08 Oct 2014
Nature Communications

Volume: 5, P: 1-13
A root cap-localized NAC transcription factor controls root halotropic response to salt stress in Arabidopsis

This study reports that the SOMBRERO, a root cap-localized transcription factor, determines root halotropic response to salt stress via spatiotemporally modulating AUX1-depdenent auxin redistribution in the root tip.

Lulu Zheng
Yongfeng Hu
Yi Han
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-12
A chip-integrated comb-based microwave oscillator

Wei Sun
Zhiyang Chen
Junqiu Liu
ResearchOpen Access30 Apr 2025
Light: Science & Applications

Volume: 14, P: 1-12
LRP6 acts as a scaffold protein in cardiac gap junction assembly

LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.

Jun Li
Changming Li
Yi-Han Chen
ResearchOpen Access02 Jun 2016
Nature Communications

Volume: 7, P: 1-11
Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume

Chao-Qi Zhang
Xu-Dong Zhang
Qiang Zhang
ResearchOpen Access18 Jun 2024
npj Science of Food

Volume: 8, P: 1-10
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit and cynomolgus monkey, identifying a new potential SAN marker.

Dandan Liang
Jinfeng Xue
Yi-Han Chen
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-15
A long-duration gamma-ray burst with a peculiar origin

Analysis of the long-duration GRB 211211A led to observations of emission properties differing from all known type I bursts, yet its multiband behaviour suggests a non-massive-star origin, pointing towards a new progenitor type.

Jun Yang
Shunke Ai
Hou-Jun Lü
Research07 Dec 2022
Nature

Volume: 612, P: 232-235
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Jing-hong Chen
Ke-xin Li
Peng Luo
ResearchOpen Access15 Apr 2025
Acta Pharmacologica Sinica

P: 1-17
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Previous observational studies of the diabetes drugs metformin vs. sulfonylureas have yielded mixed results about whether metformin reduces the risk of dementia, relative to the sulfonylureas. Here, the authors apply a novel competing risks approach to emulate dementia-related target trials in electronic health records of diabetic patients and a complementary systems pharmacology evaluation on human neural cells.

Marie-Laure Charpignon
Bella Vakulenko-Lagun
Mark W. Albers
ResearchOpen Access10 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial

The SIGNAL Phase 2 study of pepinemab immunotherapy in early Huntington’s disease (HD) did not meet its coprimary clinical efficacy endpoints, but had a favorable safety profile and showed a significant treatment-related reduction in caudate brain atrophy and reversal of the characteristic decline in brain metabolic activity that is typical of HD progression.

Andrew Feigin
Elizabeth E. Evans
Karen Anderson
ResearchOpen Access08 Aug 2022
Nature Medicine

Volume: 28, P: 2183-2193
SALL2 regulates neural differentiation of mouse embryonic stem cells through Tuba1a

Hui Xiong
Bowen Lin
Jian Yang
ResearchOpen Access30 Sept 2024
Cell Death & Disease

Volume: 15, P: 1-15
A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles

Dandan Liang
Liping Zhou
Yi-Han Chen
ResearchOpen Access07 Jun 2024
Cell Research

Volume: 34, P: 556-571
Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Xiu-chun Li
Xia-yan Zhu
Xiao-ying Huang
ResearchOpen Access08 May 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1861-1878
A review of advances & potential of applying nanomaterials for biofilm inhibition

Yi-Han Cao
Wen-Jun Cai
Jianfeng Zhou
ReviewsOpen Access20 Dec 2024
npj Clean Water

Volume: 7, P: 1-21
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells

Zheyi Lin
Bowen Lin
Yi-Han Chen
ResearchOpen Access06 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract

Xiu-Feng Huang
Lue Xiang
Zi-Bing Jin
ResearchOpen Access27 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-11
Large number of putative chemoreception and pheromone biosynthesis genes revealed by analyzing transcriptome from ovipositor-pheromone glands of Chilo suppressalis

Yi-Han Xia
Ya-Nan Zhang
Shuang-Lin Dong
ResearchOpen Access20 Jan 2015
Scientific Reports

Volume: 5, P: 1-12
Glutamate drives ‘local Ca²⁺ release’ in cardiac pacemaker cells

Duanyang Xie
Ke Xiong
Yi-Han Chen
ResearchOpen Access15 Jul 2022
Cell Research

Volume: 32, P: 843-854
Salivary proteins potentially derived from horizontal gene transfer are critical for salivary sheath formation and other feeding processes

An evolutional and functional study on bug saliva suggests that horizontally transferred genes provide a selective advantage to recipient insects by enhancing their feeding abilities.

Hai-Jian Huang
Li-Li Li
Chuan-Xi Zhang
ResearchOpen Access02 Mar 2024
Communications Biology

Volume: 7, P: 1-12
TMCO1 is essential for ovarian follicle development by regulating ER Ca²⁺ store of granulosa cells

Zhongshuai Sun
Hui Zhang
Tie-Shan Tang
ResearchOpen Access21 Feb 2018
Cell Death & Differentiation

Volume: 25, P: 1686-1701
Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation

Yiqing Yang
Jun Li
Yi-Han Chen
Research03 Apr 2009
Journal of Human Genetics

Volume: 54, P: 277-283
A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect

Xiaoping Lin
Zhaoxia Huo
Yi-Han Chen
Research15 Jul 2010
Journal of Human Genetics

Volume: 55, P: 662-667
Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer

Qun Chen
Peng Shen
Jing-Jing Zhang
Research13 Mar 2021
Oncogene

Volume: 40, P: 2772-2784
The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Wan-Li Ge
Qun Chen
Kui-Rong Jiang
ResearchOpen Access27 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-18
Functional analysis of the role of hydrogen sulfide in the regulation of dark-induced leaf senescence in Arabidopsis

Bo Wei
Wei Zhang
Yi Han
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-16
Dataset on the effects of psychological care on depression and suicide ideation in underrepresented children

Xuerong Liu
Wei Li
Zhiyi Chen
ResearchOpen Access19 Mar 2024
Scientific Data

Volume: 11, P: 1-7
LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration

Yahan Wu
Liping Zhou
Yi-Han Chen
Research24 Sept 2020
Cell Research

Volume: 31, P: 450-462
Synthesis and preliminary evaluation of novel ¹¹C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

Ji-yun Sun
Katsushi Kumata
Steven H Liang
Research13 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 491-498
Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation

Duanyang Xie
Ke Xiong
Yi-Han Chen
CorrespondenceOpen Access02 Aug 2022
Cell Discovery

Volume: 8, P: 1-4
Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy

Jun Li
Man Qi
Yi-Han Chen
Research15 Jul 2014
Cell Research

Volume: 24, P: 977-993

Search

Editorial Expression of Concern to: The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers

SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

Endothelial deletion of PTBP1 disrupts ventricular chamber development

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment ___domain

A root cap-localized NAC transcription factor controls root halotropic response to salt stress in Arabidopsis

A chip-integrated comb-based microwave oscillator

LRP6 acts as a scaffold protein in cardiac gap junction assembly

Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

A long-duration gamma-ray burst with a peculiar origin

Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial

SALL2 regulates neural differentiation of mouse embryonic stem cells through Tuba1a

A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

A review of advances & potential of applying nanomaterials for biofilm inhibition

A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells

Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract

Large number of putative chemoreception and pheromone biosynthesis genes revealed by analyzing transcriptome from ovipositor-pheromone glands of Chilo suppressalis

Glutamate drives ‘local Ca²⁺ release’ in cardiac pacemaker cells

Salivary proteins potentially derived from horizontal gene transfer are critical for salivary sheath formation and other feeding processes

TMCO1 is essential for ovarian follicle development by regulating ER Ca²⁺ store of granulosa cells

Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation

A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect

Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer

The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Functional analysis of the role of hydrogen sulfide in the regulation of dark-induced leaf senescence in Arabidopsis

Dataset on the effects of psychological care on depression and suicide ideation in underrepresented children

LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration

Synthesis and preliminary evaluation of novel ¹¹C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation

Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy

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