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Showing 101–150 of 196 results

Advanced filters: Author: Yifan Ge Clear advanced filters

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cells and that AURKA inhibition sensitizes these cells to mitotic cell death.

Junfang Lyu
Eun Ju Yang
Joong Sup Shim
ResearchOpen Access09 Oct 2020
Nature Communications

Volume: 11, P: 1-16
Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins

DNA origami orients single proteins on a surface to aid structure determination by cryo-electron microscopy.

Tural Aksel
Zanlin Yu
Shawn M. Douglas
Research19 Oct 2020
Nature Biotechnology

Volume: 39, P: 378-386
Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric hindrance for sialic acid receptor binding.

Chao Zhang
Cong Xu
Zhong Huang
ResearchOpen Access18 May 2021
Nature Communications

Volume: 12, P: 1-16
Structural basis for persulfide-sensing specificity in a transcriptional regulator

Structural and kinetic analyses of the transcriptional repressor SqrR in multiple states indicate that its persulfide selectivity is determined by structural frustration in the disulfide form, favoring formation of the tetrasulfide-bridged product.

Daiana A. Capdevila
Brenna J. C. Walsh
David P. Giedroc
Research26 Oct 2020
Nature Chemical Biology

Volume: 17, P: 65-70
Introgressing the Aegilops tauschii genome into wheat as a basis for cereal improvement

An introgression platform for transferring genetic variations of Aegilops tauschii to hexaploid wheat is established based on synthetic octoploid wheat. Combined with newly generated genome resources of A. tauschii, it represents a powerful tool for wheat gene discovery and breeding.

Yun Zhou
Shenglong Bai
Chun-Peng Song
Research27 May 2021
Nature Plants

Volume: 7, P: 774-786
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with fungal clearance.

Yifan Wu
Shuqi Du
David B. Corry
ResearchOpen Access04 Jan 2019
Nature Communications

Volume: 10, P: 1-15
Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Lipid-like nanoparticles have applications as non-viral delivery systems for mRNA. Here, the authors develop biodegradable lipids with improved clearance and reduced toxicity.

Lei Miao
Jiaqi Lin
Daniel G. Anderson
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-13
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

Cryo-electron microscopy has undergone a resolution revolution—here, this method has been combined with lipid nanodisc technology to solve structures of TRPV1, the receptor for capsaicin, in a membrane bilayer, revealing mechanisms of lipid and ligand regulation.

Yuan Gao
Erhu Cao
Yifan Cheng
Research18 May 2016
Nature

Volume: 534, P: 347-351
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Receptor Interacting Protein Kinase 2 (RIPK2) mediates innate immune signalling in response to intracellular pathogens, but its aberrant activation contributes to autoimmune pathologies. Here Nachbur et al.describe a RIPK2 inhibitor that is effective in a mouse model of multiple sclerosis.

Ueli Nachbur
Che A. Stafford
John Silke
Research17 Mar 2015
Nature Communications

Volume: 6, P: 1-13
Paclitaxel-coated balloon catheter for benign esophageal stenosis in a rabbit model

Kewei Ren
Jianan Wang
Xinwei Han
ResearchOpen Access31 Jan 2024
Scientific Reports

Volume: 14, P: 1-10
Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation

Debmalya Roy
Yifan He
Bo Zhao
ResearchOpen Access19 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

A screening approach finds VH-___domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding ___domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Colton J. Bracken
Shion A. Lim
James A. Wells
Research20 Oct 2020
Nature Chemical Biology

Volume: 17, P: 113-121
Synthesis of high-entropy materials

The emergence of high-entropy materials affords opportunities to harmonize precision and disorder for materials design. This Review highlights the synthesis principles and strategies towards controllable and predictive fabrication of high-entropy materials with complex chemical compositions, engineered microstructures and tailored atomic configurations.

Yifan Sun
Sheng Dai
Reviews03 Dec 2024
Nature Synthesis

Volume: 3, P: 1457-1470
A multiomics dataset of paired CT image and plasma cell-free DNA end motif for patients with pulmonary nodules

Mengmeng Zhao
Gang Xue
Yunlang She
ResearchOpen Access01 Apr 2025
Scientific Data

Volume: 12, P: 1-8
Hollow MnO₂ as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

MnO₂ nanostructures are promising TME-responsive theranostic agents in cancer. Here, the authors develop a nano-platform based on hollow H-MnO₂ nanoshells able to modulate the tissue microenvironment, release a drug and inhibit tumor growth alone or in combination with check-point blockade therapy.

Guangbao Yang
Ligeng Xu
Zhuang Liu
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Deep mutual learning on hybrid amino acid PET predicts H3K27M mutations in midline gliomas

Yifan Yuan
Guanglei Li
Ying Mao
ResearchOpen Access25 Nov 2024
npj Precision Oncology

Volume: 8, P: 1-13
Ironizing the martial protagonist: Jin Yong and the web novelists

Nathanael T. Booth
Yifan Zhang
ResearchOpen Access14 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-8
RBM12 drives PD-L1-mediated immune evasion in hepatocellular carcinoma by increasing JAK1 mRNA translation

Hexu Han
Qian Shi
Qiang Wang
Research26 Aug 2024
Oncogene

Volume: 43, P: 3062-3077
A Novel Ideal Radionuclide Imaging System for Non-invasively Cell Monitoring built on Baculovirus Backbone by Introducing Sleeping Beauty Transposon

Jing Lv
Yu Pan
Yifan Zhang
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Beam Steering Using Momentum-Reconfigurable Goubau Meta-Line Radiators

Xiao-Lan Tang
Qingfeng Zhang
Hao Yu
ResearchOpen Access07 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
An AI-powered navigation framework to achieve an automated acquisition of cardiac ultrasound images

Raska Soemantoro
Attila Kardos
Yifan Zhao
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Modulation recognition method of mixed signals based on cyclic spectrum projection

Weichao Yang
Ke Ren
Li Li
ResearchOpen Access05 Dec 2023
Scientific Reports

Volume: 13, P: 1-18
Continuous Beam Steering Through Broadside Using Asymmetrically Modulated Goubau Line Leaky-Wave Antennas

Xiao-Lan Tang
Qingfeng Zhang
Yifan Chen
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Real-time spectroscopic monitoring of photocatalytic activity promoted by graphene in a microfluidic reactor

Yifan Li
Beichen Lin
Miao Lu
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Breaking the Diffraction Barrier Using Fluorescence Emission Difference Microscopy

Cuifang Kuang
Shuai Li
Xu Liu
ResearchOpen Access13 Mar 2013
Scientific Reports

Volume: 3, P: 1-6
Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels.

Shangyu Dang
Shengjie Feng
Lily Yeh Jan
Research13 Dec 2017
Nature

Volume: 552, P: 426-429
Sub-bandgap charge harvesting and energy up-conversion in metal halide perovskites: ab initio quantum dynamics

Bipeng Wang
Weibin Chu
Oleg V. Prezhdo
ResearchOpen Access11 Jan 2025
npj Computational Materials

Volume: 11, P: 1-9
Land system changes of terrestrial tipping elements on Earth under global climate pledges: 2000–2100

Jiaying Lv
Yifan Gao
Peichao Gao
ResearchOpen Access27 Jan 2025
Scientific Data

Volume: 12, P: 1-14
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.

Peng Jin
David Bulkley
Yifan Cheng
Research26 Jun 2017
Nature

Volume: 547, P: 118-122
High-fidelity structured illumination microscopy by point-spread-function engineering

Gang Wen
Simin Li
Hui Li
ResearchOpen Access01 Apr 2021
Light: Science & Applications

Volume: 10, P: 1-12
Enhancing renewable energy certificate transactions through reinforcement learning and smart contracts integration

Qingsu He
Jinsong Wang
Muqing Wu
ResearchOpen Access12 May 2024
Scientific Reports

Volume: 14, P: 1-14
Establishing the robustness of chip trade networks by dynamically considering topology and risk cascading propagation

Yifan Liu
Chunpeng Du
Lei Shi
ResearchOpen Access05 Sept 2024
Scientific Reports

Volume: 14, P: 1-19
Harnessing the power of longitudinal medical imaging for eye disease prognosis using Transformer-based sequence modeling

Gregory Holste
Mingquan Lin
Yifan Peng
ResearchOpen Access16 Aug 2024
npj Digital Medicine

Volume: 7, P: 1-13
Differentially localized protein identification for breast cancer based on deep learning in immunohistochemical images

Six differentially localized proteins are obtained through protein subcellular localization prediction models constructed by deep learning in immunohistochemical images, providing support for breast cancer early diagnosis and treatment.

Zihan Zhang
Lei Fu
Wan Li
ResearchOpen Access02 Aug 2024
Communications Biology

Volume: 7, P: 1-13
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

A multivalent bi-specific nanoconjugate can promote immune cells to recognize and eradicate cancer cells in a receptor targeted manner, leading to the generation of potent and durable anti-tumour immunity.

Hengfeng Yuan
Wen Jiang
Betty Y. S. Kim
Research01 May 2017
Nature Nanotechnology

Volume: 12, P: 763-769
DNA-guided DNA interference by a prokaryotic Argonaute

Here, Argonaute from the prokaryote Thermus thermophilus is shown to use small DNA guides to interfere directly with invading foreign DNA, rather than being involved in RNA-guided RNA interference, as observed in eukaryotes.

Daan C. Swarts
Matthijs M. Jore
John van der Oost
Research16 Feb 2014
Nature

Volume: 507, P: 258-261
Probing CP symmetry and weak phases with entangled double-strange baryons

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

M. Ablikim
M. N. Achasov
J. H. Zou
ResearchOpen Access01 Jun 2022
Nature

Volume: 606, P: 64-69
Impact of circular economy on the long-term allocation structure of primary and secondary lithium

The global demand for lithium is projected to reach 1.93 million metric tons in 2050 compared to the demand in 2023, but the global implementation of recycling policies has the potential to reduce its consumption, as suggested by a bottom-up framework studying the projections of the global supply and demand of lithium for the next decades.

Yufeng Wu
Qingbin Yuan
Yifan Gu
ResearchOpen Access12 Sept 2024
Communications Earth & Environment

Volume: 5, P: 1-11
Chemical-motif characterization of short-range order with E(3)-equivariant graph neural networks

Killian Sheriff
Yifan Cao
Rodrigo Freitas
ResearchOpen Access13 Sept 2024
npj Computational Materials

Volume: 10, P: 1-10
CLUMondo-BNU for simulating land system changes based on many-to-many demand–supply relationships with adaptive conversion orders

Peichao Gao
Yifan Gao
Changqing Song
ResearchOpen Access05 Apr 2023
Scientific Reports

Volume: 13, P: 1-17
China’s CO₂ peak before 2030 implied from characteristics and growth of cities

Chinese commitments under the Paris Agreement are premised on a peak in CO₂ emissions by 2030. Using the Kuznets curve and emissions and gross domestic product data from 50 cities in the country, this Analysis predicts that emissions in China could peak between 2021 and 2025, well ahead of the Paris target.

Haikun Wang
Xi Lu
Michael B. McElroy
Research29 Jul 2019
Nature Sustainability

Volume: 2, P: 748-754
Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

Shiyu Sun
Yueqi Cai
Hua Peng
ResearchOpen Access15 Jul 2021
Cell Research

Volume: 31, P: 1011-1023
A new hybrid algorithm for three-stage gene selection based on whale optimization

Junjian Liu
Chiwen Qu
Xiaoning Peng
ResearchOpen Access07 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

Qian Hu
Yifan Zhang
Zhenyu Ju
ResearchOpen Access15 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-9
Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM

Cryo-EM and XL-MS analyses reveal the conformational landscape of TRiCmediated tubulin folding along TRiC’s ATPase cycle and the interaction sites between tubulin and the closed TRiC chamber.

Caixuan Liu
Mingliang Jin
Yao Cong
ResearchOpen Access16 May 2023
Communications Biology

Volume: 6, P: 1-14
Universal droplet propulsion by dynamic surface-charge wetting

Yifan Zhou
Jiayao Wu
Huai Zheng
ResearchOpen Access26 Sept 2024
Microsystems & Nanoengineering

Volume: 10, P: 1-10
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists

Wenjing Sun
Fan Yang
Changlin Tian
ResearchOpen Access30 Jun 2023
Cell Discovery

Volume: 9, P: 1-12
Reproducibility of ultrasound-guided attenuation parameter (UGAP) to the noninvasive evaluation of hepatic steatosis

Yanan Zhao
Minyue Jia
Pintong Huang
ResearchOpen Access21 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
An adaptive shortest-solution guided decimation approach to sparse high-dimensional linear regression

Xue Yu
Yifan Sun
Hai-Jun Zhou
ResearchOpen Access15 Dec 2021
Scientific Reports

Volume: 11, P: 1-13

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