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The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Injectable hydrogels are being explored for Rheumatoid Arthritis (RA) therapy, but most existing injectable hydrogels address only specific aspects of the RA pathological microenvironment. Here, the authors report an injectable bioadhesive and lubricating hydrogel, that prevents cartilage wear, provides long-term anti-inflammatory effects, and repairs damaged cartilage for RA therapy.

Solid electrolytes play a crucial role as ion conductors and separator between electrodes in all-solid-state batteries. Here, the authors report a high-entropy halide solid electrolyte, which reveals the structure evolution with the increasing configurational entropy and improves the high-voltage stability.

Off-target effects have limited RNA degradation approaches. Here, the authors develop a tumor microenvironment-activated ribonuclease targeting chimera (RiboTAC) demonstrating H₂O₂ and acid activated degradation of pre-miR-21, which was effective in restoring radiosensitivity in lung cancer.

Allylic amination of unactivated alkenes with aliphatic amines is a long-standing synthetic challenge in organic chemistry. This is now accomplished in an oxidant-free, site-selective process by using a combination of a photocatalyst and cobalt complex for the coupling of olefins and alkyl amines with hydrogen evolution.

Chondrocyte senescence is known to play a role in the occurrence and progression of osteoarthritis. Here, the authors demonstrate that 10-hydroxy-2-decenoic acid (10-HDA), a small molecule derived from the food nutrient royal jelly, can prevent osteoarthritis by delaying chondrocyte senescence through targeting aspartyl β-hydroxylase.

Biomaterials have potential in treating periodontitis in diabetes, but addressing the range of issues with one material is challenging. Here, the authors report the development of a redox-active hydrogel for reducing inflammation and promoting tissue regeneration in diabetic periodontitis.

Iron alloys are essential but are limited by high thermal expansion. This work reports a strategy to reduce thermal expansion by in-situ forming negative thermal expansion phases within iron alloys, while maintaining high mechanical properties.

Lipid nanoparticles (LNPs) are the preeminent drug delivery vehicle for mRNA therapies, partially due to the ionizable lipid (IL) components that facilitate endosomal escape. Here, authors devise terminally branched ILs that enhance endosome escape, resulting in increased liver and T cell delivery.

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Mouse B cells can be reprogrammed via Cas12a to express human antibodies that when affinity-matured in recipient mice generate broader and more potent antibody variants.

Developing electronic skins for sensing the spatial ___location of objects beyond two-dimensional space is difficult. The authors present a flexible, lightweight, and transparent electronic skin for non-contact accurate 3D motion sensing. This achieves micron-level precision, reducing complexity and power consumption.

The rise of large language model (LLM) technology offers new opportunities for advancing chemical synthesis. Here, the authors developed an LLM-based reaction development framework (LLM-RDF) to copilot the design and experimental tasks throughout the end-to-end chemical synthesis development.

Design and synthesis of non-noble metal catalysts is crucial for highly-efficient hydrogenation. Here, the interstitial sites in nickel are manipulated with zinc and filled by dissociated carbon atoms, which drastically improve the selectivity/stability in acetylene hydrogenation reaction.

Liu et al. developed AI-driven, wearable olfactory interfaces with odor generators for realizing latency-free mixed-reality and fast olfaction recovery. This technology enables personalized olfactory feedback and enhanced virtual environments for various applications including education, and clinical treatment.

Ethanol steam reforming (ESR) reaction is an environmentally benign and sustainable route for H₂ production. Herein, the authors demonstrate a conceptional strategy for rational design and preparation of highly-efficient catalyst toward ESR via an RhNi-TiO₂ strong bimetal-support interaction.

Quantum states are incredibly sensitive to their environment, making them perfect for ultrasensitive quantum detection—if they can be maintained long enough. Here, the authors showed that they can ‘immortalize’ the excited state of a coupled light-matter system using a technique called ‘coherent perfect absorption’.

The B-cell receptor of primary mouse B cells can be engineered to affinity mature an HIV-1-entry inhibitor in vivo.

Sintering-resistant Au nanoparticles are highly desirable due to their low Tammann temperature. Here, the authors report an ultrastable titania-supported Au nanocatalyst through an encapsulation strategy under oxidative atmosphere.

The mechanisms underlying microglia-neuron interactions are incompletely understood. Utilizing in vivo multimodal microscopy and optical clearing technology, here the authors show a distinct neuroprotective function of microglia during the acute phase of a single spinal cord axon injury.

In this study, the authors develop a comprehensive taxonomy of brain-wide SPNs, identifying several novel subsets via their transcriptional signatures.

A vanadium-based lithium-rich disordered rock salt oxide is shown to work as a low-potential anode with rapid intercalation kinetics for lithium-ion batteries.

In situ spatial transcriptomic analysis of more than 1 million cells are used to create a 200-nm-resolution spatial molecular atlas of the adult mouse central nervous system and identify previously unknown tissue architectures.

A CRISPR–Cas9 screen identifies genes that modulate long interspersed nuclear element-1 (LINE-1) expression in human cells. LINE-1 5′ UTRs have enhancer features and can activate long-range gene expression, including during zygotic genome activation.

The authors report an oviparous new specimen of the choristodere Ikechosaurus sp. from the Lower Cretaceous of China, confirming the basal archosauromorph affiliation of choristoderes. Phylogenetic analyses of this specimen along with other extinct and extant amniotes suggest that the ancestral amniote displayed extended embryo retention, including viviparity.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

IL-17 mediated inflammation in the lung is mediated by different effector molecules. Here the authors show that the epigenetic regulator epithelial sirtuin 6 (Sirt6) is associated with lung inflammation in asthma patients and that Sirt6 contributes to promotion of inflammation in mouse asthma models.

The development of sintering resistant supported Au catalysts with high activity still remains a challenge. Here the authors construct a Au-SiO₂ interface by depositing SiO₂ thin layer onto Au/TiO₂ catalyst which shows very high activity in CO oxidation even after calcination at 800 °C.

This study shows that CLASP2, a microtubule-stabilizing protein, regulates microtubule targeting via a tunable condensate interaction, offering mechanistic insights into the dynamic organization of multi-condensates in response to cellular signals.

Elastocaloric cooling is an emerging cooling technology. This work develops a ternary TiNiCu alloy based elastocaloric prototype using a roller-driven mechanism for partial kinetic energy recovery. The prototype achieved a 125% improvement in the material coefficient of performance and a 78% work recovery efficiency.

Exploring an active and cost-effective catalyst for alkaline hydrogen evolution reaction remains elusive to date. Here, the authors report the platinum single-atoms doped ruthenium/ruthenium oxides showing distinctly enhanced catalytic performance.

A type II supernova (SN 2023ixf) was observed in the galaxy M101 at a distance of 6.85  ±  0.15 Mpc, at about 1.0  h after the explosion.

Cells in the body live in geometrically constrained microenvironments. Here, Feng at al report that these constraints induce collagen IV expression which is responsible for ___location dependent bacterial adhesion.

Androgen receptor in prostate cancer (PCa) transcriptionally represses multiple genes including MYC. Here, the authors suggest that increased MYC in response to androgen deprivation contributes to castration-resistant PCa, while decreased MYC may contribute to responses to supraphysiological androgen therapy.