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Natural deep-mantle peridotites from eastern China reveal Fe-Ni alloys and Fe³⁺-rich olivine, providing direct evidence of iron disproportionation and slab recycling from the mantle transition zone beneath the eastern Asia big mantle wedge.

The interfaces in perovskite solar cells are critical to the device performance. Li et al. tune the bond strength of the interfacial molecule with the perovskite and the electron transport layer, increasing the power conversion efficiency of the cells.

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Anti-TNF CAR macrophages show anti-inflammatory efficacy in both acute and chronic inflammatory disease mouse models.

Late-stage specific and selective modifications of peptides and proteins at target residues under ambient conditions are the most facile routes to various bioconjugates. Here, the authors report an orthogonal modification of cysteine residues using alkyl thianthreium salts, which proceeds with excellent chemoselectivity and compatibility under mild conditions, introducing a diverse array of functional structures.

Neutralizing antibodies binding the ___domain III of Zika virus envelope protein (EDIII) are desired in vaccine development. Here, the authors express dimeric EDIII fused to human IgG1 Fc fragment from circular RNA, and show immunogenicity and protection in mice.

Transient optical spectroscopy applied to studying twisted MoTe₂ for time-___domain detection of fractional fillings of Chern bands reveals many hidden states that have not been previously observed and which could host exotic topological phases.

Akkermansia muciniphila can promote intestinal pathogen infection in mice via microbial metabolite succinate production, but the expansion of A. muciniphila is strictly controlled by ILC3s through the regulation of intestinal galactosylation.

Many recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the same samples using both platforms, finding only modest correlation, and compare associations with genetic variants and disease.

Rare disease DEDSSH1-associated DPH1 mutations impair eEF2 diphthamide modification that leads to eEF2 as a transcriptional coactivator for p53 to enhance expression of the cell proliferation inhibitor p21, resulting in birth defects.

Electrochemically reversible redox couples that embrace more electron transfer at a higher potential are desired for high energy density batteries. Here, the authors report a four-electron aqueous zinc-iodine battery by boosting the iodine electrochemistry in deliberately designed electrolytes.

Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with specific outcomes.

In the field of plant genome engineering, new nucleases with improved editing efficiency and alterative PAM requirements are needed. Here, the authors report a probiotic sourced CRISPR-LrCas9 system with similar PAM requirement to Cas12a and show its high efficiencies in various genome editing applications.

Pan et al. develop a versatile CRISPR-Combo platform for simultaneous genome editing (targeted mutagenesis or base editing) and gene activation in plants, representing a versatile genome engineering tool with promising applications in crop breeding.

Here the authors identify 128 regions of the genome associated with blood pressure traits in 100,000 Chinese adults. Blood pressure traits contributed differently to CVD risk, with only pulse pressure independently causally associated with carotid plaque.

The regulation of genetic diversity resulting from polyploidization and its impact on environmental adaptability remain unclear. Here, the authors show that LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

The availability of relevant animal models that can recapitulate high-risk hepatoblastoma will help to better understand its pathogenesis. Here the authors report and characterize a hepatocyte-specific, MYC-driven hepatoblastoma mouse model and show it recapitulates the human hepatoblastoma pathophysiology.

Performance improvement of cathode materials represents one of the most critical technological challenges for lithium-ion batteries. Here the authors show a close correlation between surface chemistry and phase distribution from homogeneity to heterogeneity, and its impact on the cyclic performance.

CRISPR–Cpf1 has emerged as an effective genome editing tool in animals. Now, a study shows that this system can edit plant genomes at nearly 100% efficiency at independent sites. Moreover, it can be repurposed for modulating plant transcriptome.

The balance of stem cell maintenance, differentiation, and programmed death is critical for proper development. Here they show that SNIP1 is critical for stem cell survival and differentiation in the developing brain where it acts downstream of TGFb and NFkB and regulates PRC2 activities for governing cell fates.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

CRISPR–Cas-mediated genome, epigenome and transcriptome engineering in crops is crucial as the human population grows and climate deteriorates. This Review discusses new CRISPR–Cas tools for precise engineering, and their uses in improving crop traits such as yield and tolerance to climate stresses.

CRISPR-Cas12a is a promising system for targeting AT-rich regions of the genome. Here the authors identify Cas12a orthologs with expanded targeting scope and develop a highly multiplexable editing system in rice.

A CRISPR–Cas12a promoter editing system enabled efficient engineering of quantitative trait variations of grain starch and seed size in rice, and achieved an innovative Green Revolution trait through editing of the OsD18 promoter.

The analysis of wheat cultivars reveals that variations in histone modification, rather than DNA sequence, are closely linked to the expression of nitrogen metabolism genes and distinct agronomic traits. The findings suggest that epigenetic regulation plays a crucial role in cultivar-specific adaptation to low nitrogen conditions in wheat.