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Regulation of aggregation by light is a useful phenomenon, but the role of the solvent is not often considered. Here, the authors report the development of photoinduced hydrous organic aggregates, emissive in the presence of both water and photoirradiation.

PIGEON is a statistical framework that uses summary statistics from genome-wide interaction studies to estimate how genes and environments jointly influence human complex traits.

Fluorescence imaging beyond 1880 nm has mostly been disregarded due to the water absorption peak. Here, the authors find that water absorption contributes positively to imaging and demonstrate high-contrast in vivo fluorescence imaging in the 1880-2080 nm window with the help of bright quantum dots.

Immune checkpoint blockade therapy for cancer is promising, but delivery optimization is desirable. Here the authors generate cancer-targeting liposomes with anti-PD-L1 and doxorubicin for protease-mediated intratumoral release of both components, and see effective tumor control in mouse models, thereby hinting potential clinical translation.

Blastoids are emerging models for early embryo development exploration in vitro. Here, authors found self-renewing human naïve PSCs spontaneously and efficiently give rise to blastoids upon three-dimensional suspension culture.

The authors fabricate graphene barrier films with low transmission (5·10⁻⁵g·m⁻²·d⁻¹) using reactive ion etching and oxygen plasma treatment, highlighting the importance of surface modification and intercalation in enhancing barrier performance.

Ruthenium dioxide electrocatalysts for acidic oxygen evolution suffer from mediocre activity and poor stability due to high ruthenium-oxygen covalency. Here, the authors report the effectiveness of tensile strain and electronic dopants in improving both activity and stability.

Thin films of a single-crystal dielectric—antimony oxide—can be epitaxially grown at wafer scales on graphene-covered copper surfaces and then used to transfer dielectric/graphene stacks, or be integrated as a two-dimensional dielectric onto other materials.

With the example of the paraspeckle protein PSPC1, Shao et al. demonstrated the synergistic interplay of promoter-associated RNA and its binding proteins in promoting transcription condensate formation and Pol II engagement and activity via phase separation.

In Klinefelter syndrome, gene dysregulation due to the extra X chromosome leads to delayed development of fetal germ cells (FGCs), and aberrant interactions between Sertoli cells and FGCs disrupt the migration of late FGCs to the basement membrane.

Post-prediction genome-wide association study (POP-GWAS) is a statistical framework that uses summary statistics from labeled samples with both observed and imputed phenotypes to debias single-nucleotide polymorphism effect size estimates for unlabeled samples with imputed phenotypes only, leading to valid and powerful inference.

Colorectal cancer patients with mismatch repair-deficient, but not MMR-proficient tend to benefit from immune checkpoint blockade therapy. Here, the authors identify interactions among tumor and immune cells that are associated with the responsiveness to immunotherapy in colorectal cancer.

Complex-valued neural networks can recognize phase-sensitive data in wave-related phenomena. Here, authors report a complex-valued optical convolution accelerator operating at over 2 TOPS for recognition of radar images, represents advances towards real-time analysis of complex satellite data.

The metastatic tumour microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single cell RNA sequencing analysis for synchronously resected PDAC primary tumours and matched liver metastases and find differences in cellular composition.

A multimodal model for the stratification of breast cancer risk based on clinical metadata, mammography and trimodal ultrasound images performed as well as or better than radiologists at tumour classification and at differential diagnosis.

Epigenetic regulation plays a key role in cortical development. Here the authors show that Rcor2, a co-repressor of the histone demethylase LSD1/KDM1A complex, regulates neural progenitor cell proliferation and cortical neurogenesis by repressing sonic hedgehog signaling.

Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.

Designing soft magnets with yield strengths exceeding one gigapascal while remaining ductile to prevent irreversible deformation for safe and efficient operation is challenging. The authors address this challenge by employing a nanostructuring strategy with morphologically anisotropic precipitates.

Reliable transfer techniques are critical for the integration of 2D materials with arbitrary substrates. Here, the authors describe a method to transfer 4-inch and A4-sized defect-free graphene films onto rigid and flexible substrates with controllable conformal contact, leading to improved electrical properties and uniformity.

This paper presents a virus-like lipid nanoparticle decorated with spike proteins capable of carrying antigens, including mRNA and proteins, for vaccination against SARS-CoV-2 variants.

The integrator complex is required for the synthesis of protein coding and non-coding RNA and contains the protein INTS13. Here, the authors find germline mutations in INTS13 in two families with oral facial digital syndrome and show that the mutation affects the c-terminal ___domain of the protein and disrupts cilliogenesis.

Crystallization-induced photoluminescence weakening in ultrasmall metal nanoparticles is not well understood. Here, the authors study conformational isomers of gold nanoclusters to examine the effect of interparticle distance on this phenomenon, and propose a model of distance-dependent non-radiative excitation electron transfer.

Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.

Single cell sequencing often omits certain cell types due to technological constrains. Here the authors report an algorithm called BulkTrajBlend, part of OmicVerse, which fills gaps in single-cell RNA-seq by using Bulk RNAseq data to restore missing cells and improve analysis.

Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate at the naïve branch.

Rechargeable solid-state sodium-ion batteries hold great promise for safer and more energy-dense energy storage. Here, the authors show a new sodium-based halide, Na_3-xY_1-xZr_xCl₆, for sodium-all-solid-state batteries with enhanced ionic conductivity and long-term cycling stability.

Structural and biochemical analyses identify Nudt12 as a novel mRNA deNADing enzyme in mammalian cells, which has a different substrate preference compared to the deNADing enzyme DXO.

Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemia cells at diagnosis, residual and relapse stages, uncovering the hypoxia pathway as a potential target for residual leukaemia cells.

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

The frameshift stimulation element (FSE) of coronaviruses is an RNA structure that is required for balanced expression of viral proteins and is thus a promising drug target. A structure of the SARS-CoV-2 FSE serves as a guide for the development of antisense oligonucleotides that impair virus replication.

The software Optimer has aided the programmable one-pot oligosaccharide synthesis with a library of 50 Building BLocks (BBLs). Here, the authors expanded Optimer's validated and virtual libraries of BBLs and developed Auto-CHO, a software which allows the one-pot programmable synthesis of more complex glycans.

The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.

A study profiled transcriptomic characteristic of circulating immune cells in preeclampsia pregnancy by scRNA-seq, then develop cell-type-specific models to identify potential diagnostic indicators of preeclampsia by machine learning.

The molecular mechanism of broad-spectrum neutralization of a rabbit monoclonal antibody 1H1 against Omicron sublineages is revealed by cryo-EM.