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A Leptotrichia buccalis Cas13a diagnostic platform can be used to cleave and detect small concentrations of viral and human DNA.

Reducing platinum use is vital for sustainable hydrogen production via proton exchange membrane water electrolysis. Here, the authors report a Mo₂TiC₂ MXene-supported platinum nanocluster catalyst that requires minimal platinum content and operates efficiently for over 8700 h.

Zheng et al. report water vapor treatment for in-situ n-doping of ZnMgO, enabling ideal ohmic electron transport and hole blockage as the electron injection layer for quantum dot light-emitting diodes, and improving the brightness and power efficiency of R/G/B LEDs for general lighting.

Rare drug-drug interactions pose risks but are challenging to predict due to data scarcity. Here, the authors present RareDDIE to enhance rare interaction prediction through dual-granular structure-adaptive learning pair variational representation.

Platinum nanoclusters comprising about ten atoms each made by reducing isolated platinum cations in CeO_x nests isolated on high-area silica are demonstrated. Two forms of platinum were reversibly interconverted by oxidation/reduction, remaining stably confined to the nests even under severe conditions, in H₂ at 600 °C and under atmospheric pressure.

Jiang et al. propose a kirigami-based, mechanically reconfigurable metasurface that utilizes simple uniform stretching to achieve unexpected and dynamic beam steering functions. This unique approach modifies the geometric phase and lattice constant synchronously based on the rotation of anisotropic meta-atoms, exhibiting extended degree of freedom and wave-tuning ranges.

Triplet nitrenes are highly reactive species and thus their isolation and characterization are challenging. Now, a bulky hydrindacene ligand has been used to stabilize a triplet arylnitrene synthesized through photolysis of an azide precursor under mild conditions. The triplet nitrene has been fully characterized by various techniques including single-crystal X-ray diffraction, electron paramagnetic resonance spectroscopy and theoretical calculations.

Late-stage acute liver failure (ALF) has limited therapies. The authors show that the bioactive compound SCM-198 extends the ALF treatment window from 3 to 24 hours in mice by selectively targeting the identified AdipoR2-CaM-CaMKII-NOS3-NO axis.

Phosphanorcaradienes can serve as synthons for transient phosphinidene but the synthesis remains challenging. Here, the authors report a synthesis protocol for a phosphanorcaradiene, in which one of the benzene rings is intramolecularly dearomatized through attachment to the phosphorus atom.

In this study, the authors report a potent neutralizing antibody targeting a conserved epitope within RSV pre-F that shows higher antiviral activity against both RSV-A and -B subgroups in vitro and in small animal models than FDA-approved prophylactic agents.

Reducing CO₂ to CH₃COOH using visible and near-infrared light is challenging. Here, Wu and Zhang et al. incorporate Au nanoparticles and single atoms into Mo-edge-rich MoS₂ to provide a pathway to overcome limitations and boost productivity.

Xia et al. provide a method for deep learning of 3D facial images to predict biological age with an accuracy of ±2.8 yr from chronological age and its correlation with lifestyle indicators and blood transcriptomic age.

The seawater oxidation reaction faces challenges from competitive chloride oxidation reaction. Herein, the authors have utilized chlorine adsorption to modulate the single-atom Ir coordination state and promote seawater oxidation and catalyst stability.

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

Controlling the reaction path is instrumental for developing efficient catalysts for CO₂ hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve selective hydrogenation of CO₂ into methanol relative to nanocrystal counterparts.

Heavy analogues of carbynes of the type R–\({{{\dot{\mathrm E:}}}}\), where E is a group 14 element, are difficult to isolate in the condensed phase due to their high reactivity. Now, a germylyne radical supported by a sterically hindered hydrindacene ligand has been prepared and structurally characterized. Theoretical calculations show that the spin density mainly resides at the germanium centre.

DNA 6mA is a poorly understood epigenetic mark present at a low abundance in eukaryotic genomes. Here the authors observe high levels in zebrafish and pig during early embryogenesis enriched to repetitive regions of the genome and followed by attenuation during development.

TPC2 is an important organellar Na⁺/Ca²⁺ release channel which regulates function of lysosomes and lysosome-related organelles. Here, Wang et al. demonstrate that a gain-of-function mutation (R210C) in TPC2 leads to hypopigmentaion, enlarged endolysosomes, enhanced lysosomal Ca²⁺ release and hyper-acidification.

Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P₂ to PI(3,4,5)P₃ and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P₃ extends worm lifespan and alleviates worm as well as mouse health decline during aging.

Boosting activity of oxide catalysts is a long-lasting challenge to developing efficient catalysts for industrially important reactions such as CO₂-to-methanol. Here, the authors report a strategy for enhancing the activity of a ZnZrO_x methanol synthesis catalyst via engineered nanoscale H supply.

Nanometre-sized ‘nanoglue’ islands of CeO_x on high-surface-area SiO₂ are shown to suppress sintering and confine on average one Pt atom per island, leading to stable single-atom catalysts under oxidizing and reducing environments.

Despite many advantages of vat photopolymerization in microfluidic device fabrication, well-controlled μm-sized (< 100 μm) channels in the layer building direction remains a challenge. Here, authors present a general high resolution and low-cost 3D printing process that can produce devices within the 10 μm scale.

In 451,233 Chinese adults, Sun et al. find that five aspects of a healthy lifestyle are together associated with longer total life expectancy and a larger proportion of remaining years lived without major non-communicable diseases.

Hydrogenation of CO₂ over heterogeneous catalysts can produce useful energy vectors such as methanol and formic acid. Here the authors show that the activity of unsupported cobalt catalysts can be markedly enhanced through incorporation of nitrogen atoms into the structure.

Circular RNA circFNDC3B regulates osteoarthritis progression via oxidative stress and HO-1/ NF-κB signalling pathways.

Recent years have witnessed substantial potential in allying meta-optics with diverse waveguide platforms to enable exotic manipulation of guided light signals. This review cataloged recent advances on meta-waveguides for photonic integration.