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The authors integrate artificial intelligence with laboratory automation to create a widely applicable autonomous platform for efficient and scalable enzyme engineering.

NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

The authors present experimental evidence of three-dimensional superinsulation in a nanopatterned slab of NbTiN. In the electric Meissner state, they find polar nematic order arising from ferroelectric alignment of short electric strings excited by external electromagnetic fields.

2D semiconductors are attracting attention as a potential alternative for post-silicon electronics, but the fabrication of high-performance 2D p-type transistors remains a challenge. Here, the authors report the realization of bilayer WSe₂ p-type transistor arrays with on-state currents up to 421 μA/μm, on/off ratios exceeding 10⁷ and subthreshold swings as low as 75 mV/decade.

Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

Achieving uniform Li plating in solid-state batteries is key for their practical application. Here, the authors integrate a silver-doped lithium argyrodite layer in initially anode-free all-solid-state batteries, promoting uniform lithium plating and cell operation under a low stack pressure of 2 MPa through silver exsolution.

Freestanding membranes of hafnium zirconium oxide can be created using pulsed laser deposition method and used as the top-gate dielectric in molybdenum disulfide transistors.

Authors introduce an unsupervised framework for automatic modulation recognition. By using multi-___domain signal representation and contrastive learning, it extracts high-quality features from unlabelled data, outperforming existing methods and reducing the need for labelled samples in wireless communications.

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

Spin-waves have a variety of advantages for information processing, and here, Chen, Xu and coauthors demonstrate the deterministic switching of antiferromagnetic spin textures using non-linear spin-waves. The switching process is progressive, mirroring weighted sum operations in neuromorphic computing.

Employing appropriate catalysts in room-temperature sodium-sulfur batteries can significantly enhance performance. Here, authors utilize natural language processing techniques in conjunction with a binary descriptor to screen preferrable single-atom catalysts to achieve high specific capacity.

The development of vertical p-i-n junctions has been hindered by complex fabrication techniques and performance trade-off between responsivity and speed. Here, authors employ WSe₂ thin layers to construct photodiode, reporting responsivity of 0.388 A/W and response time down to sub-10 picoseconds.

Controlling molecular transport across immiscible liquid interfaces is vital for applications in biotechnology, manufacturing, and space research. Here, the authors show that unsteady temperature fields drive directional water transport across oil-water interfaces via Marangoni natural convection, enabling tunable, surfactant-free nanoemulsion formation.

This study shows that terrestrial heatwaves either propagate or remain stationary along preferred pathways, influenced by Rossby wave activity. The results provide potential for heatwave predictability.

Cytosine base editors use an uracil-containing intermediate to introduce C•G to T•A and C•G to G•C point mutations. Here, the authors couple gene knockdown with reporters of these two cytosine base editing outcomes to identify the cellular DNA repair factors that process this intermediate.

Electrification is a promising way to decarbonize the chemical industry but could also have important effects on power systems. Here the authors assess the impact of electrifying the production of methanol and ammonia on the Chinese power system in terms of emissions and potential security risks.

Wang, Tang and colleagues develop the low-signal signed iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near CCDC141, IGF1R, TTN and TNKS loci, and show that hypertrophy in induced pluripotent stem cell-derived cardiomyocytes is nonadditively influenced by interactions among CCDC141, TTN and IGF1R.

Traditional tactile systems suffer from the physical separation between sensing and processing units, causing latency and power issues. Here, Chen et al. report a capacitive in-sensor tactile computing system, using sensor networks to execute in-situ multiplication and accumulation operations.

Yu-Shiba-Rusinov (YSR) states result from the exchange coupling between a localized magnetic moment and a superconductor. Traditionally, the YSR states have been studied for magnetic atoms. For molecular magnets with extended ligand spin, the entanglement of spin and ligand orbital gives rise to new forms of YSR excitations. Here, Xia et al uncovered spin-orbital YSR states in an unpaired ligand spin in the molecular magnet Tb2Pc3 on Pb.

Optical frequency combs power technologies like communication but face stability issues in miniaturization. Here, authors present a self-locked microcomb in a lithium niobate chip by combining electro-optic, Kerr, and Raman effects, achieving a 300 nm span and low noise without external feedback.

Understanding how global changes affect both aboveground plants and belowground soil organisms is essential for preserving ecosystem functions and biodiversity. This study synthesizes extensive data, revealing decoupled responses in plant and soil biota to global changes across different biomes.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

The interplay between electronic topology and superconductivity is of great current interest in condensed matter physics. Here, the authors unveil an unconventional two-dimensional superconducting state accompanied by a van Hove singularity in the recently discovered Dirac nodal line semimetal ZrAs₂, which is exclusively confined to the top and bottom surfaces.

OmiCLIP is a visual–omics foundation model that integrates histology and spatial transcriptomics. The associated Loki platform offers accurate and robust tools for alignment, annotation, cell-type decomposition and spatial gene expression prediction.

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Although iron is essential, its absorption is inefficient; this study uncovers distinct iron uptake strategies in Drosophila, including a previously unrecognized high-affinity system activated during iron starvation.

The authors use inelastic neutron scattering to map out the spin excitations of FeSe dewtinned with a uniaxial-strain device. They establish a spin-interaction phase diagram and conclude that FeSe is close to a crossover region between the antiferroquadrupolar, Néel, and stripe ordering regimes.

InterpolAI leverages optimal flow-based artificial intelligence to produce synthetic images between pairs of images for diverse three-dimensional image types. InterpolAI is more robust and accurate than existing methods, improving data quality for downstream analysis.

The pairing mechanism in kagome superconductors is still not fully understood. Now, CsV₃Sb₅, which belongs to this family, is shown to have orbital-selective pairing with two distinct superconducting domes that are not separated by any phase boundary.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

The authors demonstrate standing ceramic circuit boards (S-CCBs) with high-resolution and high aspect-ratio fabricated via sacrificial coating-assisted micro-3D printing, which have both high-density integration and large current-carrying capacity

Diffusion models have shown promise in content generation, however, like many forms of generative AI, this comes with high computation cost, exacerbated by standard von Neuman computing architectures. Here, Cheng et al present a magnetoelectric memory for in-memory computing and demonstrate diffusion-based image generation on an 80×80 array.

A general two-step intercalation and cation-exchange strategy is used to produce a library of highly ordered magnetic intercalation superlattices with tunable chemical modulations and magnetic ordering.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Existing cell type deconvolution methods, crucial for studying tumour environments, overlook some critical issues. Here, authors analyse how these issues impact on deconvolution and develop methods to counter them, significantly enhancing cell type percentage prediction accuracy of mixtures.

Lilies are popular ornamental and medicinal plants with gigantic genomes. This study reports a high-quality genome assembly of royal lily (Lilium regale), revealing its transposon-driven genome expansion and epigenetic mechanisms for adaptation, offering a resource for lily research and breeding.

Nonlinear transport has recently been shown to allow efficient detection of the Néel vector, however, antiferromagnets hosting nonlinear transport are assumed rare, due to the required strong spin-orbit coupling. Here, Zhu, Li and coauthors find that the magnetic order itself can yield large nonlinear transport.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Transition metal dichalcogenides exhibit diverse and tunable electronic states. Here the authors reveal a cascade of phase transitions upon increasing hydrostatic pressure in the few-layer 1T’-WS₂, including a re-entrant superconducting phase emerging from a normal state exhibiting anomalous Hall effect.

EpiVerse is a deep-learning framework that integrates imputed epigenetic signals to improve cross-cell-type Hi-C prediction, enhance interpretability, and enable in silico perturbation of chromatin architecture.

Activation of brown adipose tissue can ameliorate obesity and diabetes. Here the authors show that chemical inhibition of hyaluronan synthesis by 4‐methylumbelliferone or genetic deletion of hyaluronan synthases 2 and 3 decreases body-weight gain and improves glucose homeostasis by inducing the thermogenic capacity of brown adipose tissue in mice.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

Using a grating-based mode-splitting and reflector approach, a bidirectional chip-scale nanophotonic Kerr-resonator circuit that consumes 97% of the pump power to generate a soliton frequency comb at approaching unit efficiency with 65% conversion efficiency is reported.

The dynamic spatial chromosomal configurations in 3D space demonstrate cell-to-cell variation. Here, authors develop Tensor-FLAMINGO to reconstruct high-resolution single-cell specific 3D genome structures, leading to insights into chromatin folding, gene regulation and disease SNPs.

A universal, high-resolution printing technology for metal oxide thin-film transistors is still lacking. A plasmonic printing technology is reported to fabricate high-performance, solution-processed all-metal oxide thin-film electronics under room temperature and ambient conditions.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.