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Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

A wristband combines continuous glucose monitoring with real-time detection of physiological signals to track glucose metabolism.

DNA-coated colloids have failed to achieve their promise of programmable self-assembly because they stick to each other like Velcro. Here Wang et al.overcome this problem by making clickable smooth colloids that are coated with short single-stranded DNA at high density.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Cities serve as climate change laboratories for phenology studies. Here, the authors show that results of such studies should be interpreted with caution, as urban-rural phenology gaps are primarily driven by species composition differences rather than temperature differences.

The molecular characterisation of soft tissue sarcomas (STSs) across diverse populations remains crucial. Here, the authors perform a proteomics and phosphoproteomics analysis of 272 Chinese STS patients across 12 subtypes, and obtain insights related to progression, metastasis, and immune signatures.

Convective self-assembly of particles is widely employed, but some fundamental aspects remain unknown. Here, the authors perform an in-situ SAXS study during the convective self-assembly of colloidal particles at the meniscus, which provides mechanistic insights.

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

SCUBA-D is a denoising diffusion probabilistic model that can perform a variety of protein backbone design tasks, including generation of backbones from random noise, from user-sketched designs, and backbones to scaffold predefined motifs that can bind small molecules or other proteins.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

A two-step, video-based deep learning model is developed to first screen for cardiac anomalies using noncontrast magnetic resonance imaging, followed by diagnosis of 11 types of cardiovascular disease using gadolinium enhancement-based imaging.

Nonlinear light-matter coupling has applications in quantum technologies, for instance in quantum-non-demolition measurements, but its strength is typically limited. Here the authors demonstrate near-ultrastrong nonlinear light-matter coupling in a superconducting circuit with two transmons and a quarton coupler.

Activated carbon has been widely used for PFAS adsorption, but this method generates secondary solid wastes. The flash Joule heating approach realizes mineralization of PFAS and generation of useful flash graphene in waste granular activated carbon.

Here the authors discover that furanodienone (FDN), a small molecule derived from ginger, exhibits PXR agonist activity selective for the intestine and show that when FDN is administered orally in pharmacological doses ameliorates induced colitis in male mice.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

The administration of therapeutics for chronic disease management faces challenges like precise dosage control and timely delivery. This Review explores how smart closed-loop systems can address these issues by integrating real-time biosensing with automated drug delivery, highlighting advancements in wearable and implantable technologies, artificial intelligence-enhanced control algorithms and the integration of synthetic biology for personalized, adaptive therapies.

Mycobacterium tuberculosis (M.tb) infection of human alveolar macrophages reveals a variably expressed gene network with inter-individual variability, guiding future studies to determine individual risk of M.tb infection and tuberculosis disease.

Genetically-encoded indicators with more red-shifted excitation and emission wavelengths are advantageous for in vivo imaging. Here, Dalangin et al. report the engineering of far-red fluorescent Ca2+ indicators and demonstrate their utility for monitoring of all-optical cardiac pacing in embryonic zebrafish.

Metallic bone scaffolds can’t be soft and strong. Here, the authors design a two-stage metamaterial scaffold with decoupled strength and modulus. By inducing greater tissue strain, it enhances osteogenesis and angiogenesis in ulnar defects model.

NCOMMS-24-44031B Nanozymes have found wide applications in various fields, but the deviation between the working and optimal pHs of nanozymes limits their practical applications. Here, the authors report a strategy to modulate the microenvironmental pHs of metal–organic framework nanozymes, enabling them to exhibit optimal activity under neutral pH conditions.

Preparing triangulene-based high spin structures is of interest for molecular spintronics. Here, the authors generate high spin triangulene trimers on Au(111) via a surface-assisted dehydration reaction.

High-surface-area corundum are used in ceramics and catalyst supports, yet the synthesis is hampered by high energy barrier and aggregation. Here the authors report the ultrafast synthesis of corundum nanoparticles via the resistive hotspot triggered phase transformation in electric heating process.

Indica rice has higher nitrate assimilation and nitrogen use efficiency (NUE) than japonica rice, but the mechanism is unclear. Here, the authors reveal that the difference is partly due to allelic variation of a nitrate reductase encoding gene and this indica allele can increase yield potential and NUE.

Zinc-ion electrochemical cells are limited by cycling stability and low electrode utilization. Here, authors present designs to enhance the cumulative capacity of zinc-ion supercapacitors by reducing zinc dendrites and increasing porous carbon activation, improving capacity and cycle life.

The relevance of spliceosome core components in cancer is less understood. Here the authors show SmD2, a core component of the spliceosome machinery, is under acetylation-dependent regulation, which could be targeted to enhance sensitivity to PARP inhibitors in hepatocellular carcinoma.

ReaL-MGE (Recombineering and Linear CRISPR/Cas9 assisted Multiplex Genome Engineering) enables precise insertion of large DNA sequences in multiple species. Here, authors demonstrate its utility in enhancing malonyl-CoA levels and producing valuable compounds like epothilone from lignocellulose.

A general method of creating colloidal particles that can self-assemble into ‘colloidal molecules’ is described: surface patches with well-defined symmetries are functionalized using DNA with single-stranded sticky ends and imitate hybridized atomic orbitals to form highly directional bonds.

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Hydrogen storage and release are critical issues for commercial use. Here, authors report a Fe Foam with amorphous domains for the hydrolysis of ammonia borane with ultra-long lifetime over 900 h, realizing the on-board H₂ supply of a model car.

A key challenge in robotics is leveraging pre-training as a form of knowledge to generate movements. The authors propose a general learning framework for reusing pre-trained knowledge across different perception and task levels. The deployed robots exhibit lifelike agility and sophisticated game-playing strategies.

Free-standing nitrogen-doped amorphous monolayer carbon consisting of mixed five-, six- and seven-membered rings was prepared through the polymerization of pyrrole within the confined interlayer cavity of a removable layered-double-hydroxide template.

Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

A deep learning method for protein sequence design on given backbones, ABACUS-R, is proposed in this study. ABACUS-R shows an improved performance when compared with conventional energy function-based methods in wet experiments.