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CT scans are routinely used to diagnose pneumoperitoneum. Here the authors present a deep learning model for detecting pneumoperitoneum in abdominal CT scans, validated on datasets from Taiwan and the US, showing high accuracy and potential to accelerate diagnosis and treatment in emergency care.

Realising scalable entangled photon sources with quantum dots requires compensating for both wavelength mismatches and exciton fine-structure splitting (FSS). So far, multiple QDs with the same emission wavelength and near-zero FSS have not been demonstrated. Here, the authors fill this gap, reaching high entanglement fidelity for multiple QDs tuned into resonance with each other or with Rb atoms.

This randomized trial assessed the effectiveness and safety of single blastocyst transfer vs single cleavage-stage embryo transfer among women with good prognosis. Here, the authors show improved cumulative live birth rates and relatively unfavorable perinatal outcomes after blastocyst transfer.

Precise and spatio-temporal control of crystallization kinetics is important but challenging. Here, the authors propose an optical strategy called optofluidic crystallithography to steer the growth of single-crystalline halide perovskites.

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Multiple pathogenic viruses are identified in a large set of pangolins, which shows that trading pangolins for scales or flesh may increase the risk of emergence of viral infections.

The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.

T-cell immunity is driven by the interaction between peptides presented by major histocompatibility complexes (pMHCs) and T-cell receptors (TCRs). Only a small proportion of neoantigens elicit T-cell responses, and it is not clear which neoantigens are recognized by which TCRs. The authors develop a transfer learning model to predict TCR binding specificity to class-I pMHCs.

The authors seek to understand the precise roles of microglia in the early human brain by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent stem cells (iMac).

scHOT enables detection of changes in higher-order interactions in single-cell gene expression data.

An organic molecule, 5Cz-TRZ, with multiple donor units supports fast reverse intersystem crossing, allowing fabrication of high-performance organic light-emitting diodes.

Implanted bioelectronic devices have proven useful for health sensing and therapy, while the interconnection of distributed implants remains challenging. Here, the authors demonstrate direct implant-to-implant wireless networking at the scale of the human body using metamaterial textiles.

Experimentally probing the orbital population is highly desirable to resolve the redox mechanism of cathodes materials. Here the authors quantify the orbital populations of Co and O in LiCoO₂ and identify the ligand-to-metal charge transfer.

Although single atom catalysts (SACs) with high-loading metal-Nx have great potential in heterogeneous catalysis, their scalable synthesis remains challenging. Here, the authors develop a general cascade anchoring strategy for the mass production of a series of metal-Nx SACs with a metal loading up to 12.1 wt%.

Here, with the state-of-the-state electron microscope, the authors report three-dimensional atomic-scale observation of LiNi_0.5Mn_1.5O₄ from various directions, revealing unprecedented insight into the evolution of both atomic and electronic structures during delithiation.

Optically active defects in hBN are promising for quantum sensing and information applications, however, coherent control of a single defect has not been achieved so far. By using an efficient method to produce arrays of defects in hBN, Guo et al. isolate a new carbon-related defect and show its coherent control.

Seeking eco-friendly materials with equivalent performance to lead-based piezoelectric materials remains an urgent demand. Here, the authors design potassium–sodium niobate-based lead-free piezoelectric materials with large potential.

We discovered that liquid metal endowing negative mixing enthalpy with other elements could provide a stable thermodynamic condition and act as a desirable dynamic mixing reservoir, realizing the synthesis of high-entropy alloy nanoparticles.

The Drosophila R8 photoreceptor separates signals for image perception and circadian photoentrainment by co-releasing histamine and acetylcholine, and this segregation is further established in the postsynaptic circuitry in the medulla.

Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating GLP-1 levels through suppression of hepatic CYP8B1 expression and bile acid mediated inhibition of intestinal FXR signalling.

Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT₆R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT_2CR.

Intestinal ischemia/reperfusion (I/R) injury is a life-threatening problem in surgeries. Here, authors report that intestinal organoids transplantation attenuates intestinal I/R injury in mice through L-Malic acid-mediated M2 macrophage polarization.

CD133 and Notch1 double-positive GSCs were preferentially located along Jagged1-expressing white matter tracts, which exhibited a demyelinated phenotype. The NOTCH1–SOX9–SOX2 positive-feedback loop controls GSC invasion along white matter tracts.

A full kinetic pathway of a non-classical nucleation-induced phase transformation through metastable states is elucidated at sub-ångström resolution in a technologically important titanium alloy.

Imperfections can greatly alter a material’s properties. Here, the authors investigate the influence of point defects on the electronic structure, charge-carrier mobility and optical absorption of molybdenum disulphide prepared by mechanical exfoliation, physical and chemical vapour deposition.

Identifying new, active material phases provides a promising avenue in the development of efficient catalysts. Here, authors demonstrate a metastable 1T-phase IrO₂ metallene oxide as an oxygen evolution electrocatalyst in acidic electrolytes.

Volatile organic compounds such as benzene are toxic pollutants that cause health issues even at trace concentrations. Here, a double-walled metal–organic framework is presented that demonstrates high uptake at very low pressures (<10 Pa), allowing the removal of benzene to below acceptable indoor limits.

An interfacial assembly strategy was developed to construct single-atom binary Fe/Co-Nx sites with a high accessible site density of 7.6 × 10¹⁹ sites per gram which results in increased power densities in fuel cells and Zn/air batteries.

The moth Plutella xylostella during its larval stage is the host of the endoparasitic wasp Cotesia vestalis. Here the authors show that the parasitoids deliver microRNAs to their hosts through their symbiotic virus and specialized cells leading to induced developmental delay.

2D COFs are promising for resistance-related applications, but usually form powders where poor contacts at grain boundaries inhibit the conductivity. Here authors show that halide perovskites can act as electric glues to bond 2D COFs to improve their conductivity, activating them to detect NO₂ with high selectivity and sensitivity.

LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.

Efficient anion recognition and trapping is of great significance for anion-specific separation processes but the design of an anion-adaptive sorbents remains a challenge. Here the authors use a cucurbit[8]uril based soft cationic supramolecular material as efficient sorbent for TcO₄⁻ ions.

Flexible batteries have been used to power wearable smart electronics and implantable medical devices. Here, the authors report a carbon-rich flexible hydrogen substituted graphdiyne electrode exhibiting superior electrochemical performance in lithium and sodium ion batteries.