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The electrochemical stability window and Li⁺ transport limit the energy-dense and fast-charging capability of lithium metal batteries. Here, authors report a trifluoride ether-based electrolyte to stabilize energy-dense lithium metal batteries under high current rates.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Chemical reduction of alkali cations to their metals is extremely challenging. Here, the authors synthesized a series of redox-active borate anions stabilized by bipyridine ligands which can reduce lithium ions generating elemental lithium metal and borate radicals.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

This study reveals the autocatalytic growth of Li₂S crystals at the solid-liquid interface in lithium-sulfur batteries enabling good electrochemical performance under high loading and low electrolyte conditions.

mGWAS reveals ZmICE1 as a key hub for integrating amino acid metabolic pathways and cold tolerance in maize. Natural variation in ZmICE1 promoter regulates the binding affinity of ZmMYB39, which confers the diverse cold tolerance in maize.

Spectral inhomogeneity of solid-state quantum emitters hinders their application in scalable quantum networks. Here the authors use in-situ 3D strain engineering at cryogenic temperatures to independently tune emission energy and suppress fine structure splitting in quantum dots embedded in photonic structures.

Histone crotonylation is implicated in transcriptional regulation. Here, the authors perform genome-wide mapping of histone crotonylation in mouse and human early embryos. Suppression of histone crotonylation results in developmental arrest at 2-cell stage due to impaired transcriptional activity. Embryos from aged female mice exhibit diminished histone crotonylation, while sodium crotonate supplementation facilitates blastocyst formation.

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

The two-dimensional layered crystal structure of niobium oxide polymorph T-Nb₂O₅ exhibits fast Li-ion diffusion that is promising for energy storage applications. Epitaxial growth of single-crystalline T-Nb₂O₅ thin films with ionic transport channels oriented perpendicular to the surface are now demonstrated.

Wan, J. Shi, M. Shi, Huang et al. report a role for lactate dehydrogenase B in regulating CD8⁺ T cell disulfidptosis and exhaustion through the activity of glucose-6-phosphate dehydrogenase, thereby impacting the efficacy of antitumour immunity.

Xu et al. establish the importance of H2A.Z in mouse oocyte development. H2A.Z is incorporated into chromatin at promoters and putative enhancers, and its presence promotes histone acetylation in fully grown oocytes.

Nanopore direct RNA sequencing is promising for epitranscriptome study but remains limited in single-molecule resolution. Here, the authors develop SingleMod, a tool for accurate single-molecule m6A detection from DRS and reveal cross-species epitranscriptome landscapes at single-molecule level.

Poor mechanical stability under high humidity remains a critical challenge for flexible perovskite solar cells. Here, the authors develop a bioinspired dopamine containing polymer to enhance adhesion in humid environments, achieving an efficiency of nearly 26%.

Low ion conductivity, large interfacial resistance, and dendrite growth hinder the practical use of solid-state batteries. Here, the authors introduce a self-healing poly(ether-urethane)-based solid-state polymer electrolyte to address these issues, resulting in high performance solid-state lithium-sulfur batteries.

Development of lithium metal anodes is limited due to the dendritic growth and high reactivity of metal lithium. Here authors propose a surface modification strategy using heptafluorobutyric acid to form a lithiophilic interface, which enables uniform Li deposition and improving battery performance.

Large lattice variation of electrode materials upon lithiation and delithiation limits the cycle life of lithium batteries. Here, authors introduce a lattice pinning strategy via heterostructure design to suppress lattice expansion in MoO₃ and improve cycle life in all-solid-state lithium batteries.

Phase-switchable preparation of two-dimensional WS₂ is achieved through an electrochemical Li⁺ intercalation-based exfoliation strategy. A low discharge current density with high cutoff voltage produces pure semiconducting 2H phase WS₂ bilayers, while a higher discharge current density with a lower cutoff voltage favours semimetallic 1T′ phase WS₂ monolayers.

HwMR, a microbial rhodopsin from Haloquadratum walsbyi, thrives in MgCl₂-rich environments and functions as an inward Mg²⁺ transporter, revealed through structural and functional analyses.

Here, Song and Li et al. show that autophagy-related 8 (Atg8) recruits Atg1 to the surface of autophagosomes to coordinate membrane expansion of the autophagy machinery. Artificial tethering of the Atg1 kinase ___domain to autophagosomal membranes boosts autophagy in multiple species.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

Li-rich layered oxide cathodes show high capacities in Li-ion batteries but suffer from structural degradation via O–O dimerization. Here, the authors present local-symmetry-tuned Li₂RuO₃ with oxygen redox involving a telescopic O–Ru–O configuration avoiding O₂ release, enhancing cycling stability.

The authors reveal nearly two-order magnitude of decoupling of the mean free path of the dominant electrons to that of phonons in Bi-Sb alloy, achieving an atomically homogeneous, coarse-grained sample through ultrafast quenching, enabling thermoelectric cooling down to the liquid nitrogen regime.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

High mobility group A1 (HMGA1) has been identified to play a role in tumour progression but its involvement in anti-tumour immunity of esophagael squamous cell carcinoma (ESCC) remains unclear. Here the authors report that the inhibition of STING-mediated anti-tumour immunity by HMGA1 results in promotion of ESCC tumorigenesis.

Lithium metal batteries (LMBs) with inorganic solid-state electrolytes suffer from lithium dendrites propagation. Here, the authors demonstrate the production of stable lab-scale LMBs using an Ag-coated Li_6.4La₃Zr_1.7Ta_0.3O₁₂ inorganic solid electrolyte in combination with a silver-carbon interlayer.

Short-term sea-level fluctuations during climatic oscillations result in divergent variations in global mangrove growth across ocean basins, according to analyses of satellite observations from 2001 to 2020.

A long-chain alkylamine strategy enables stable halide double perovskite sensors with CO detection as low as 20 ppb and ambient air durability up to 270 days, achieving excellent sensitivity and stability.

Endosomal escape is the major limitation in LNP delivery efficency. Here, the authors report on endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing by integrating the chloroquine scaffold into ionizable lipids, demonstrating improved transfection in vivo.

How to achieve ideal antiferroelectricity with sharp switching in nanoscale thin films remains challenges. The authors here unveil the selective stepwise transition, achieve ideal antiferroelectricity with large digital electrostrain in PbZrO₃ epitaxial thin films.

Solid-state sodium batteries using halide electrolytes face ionic transport limitations and (electro)chemical instability. Here, authors design fluorinated amorphous sodium halides via vacancy-carrier optimization and fluorination-driven amorphization, enhancing discharge capacity and cycle stability in Na₃V₂(PO₄)₃-based all-solid-state batteries.

The authors make a terahertz device utilizing collective electronic states in 1T-TaS₂ that achieves reconfigurable logic operations through dynamic charge-density-wave phase manipulation. The device shows exceptional performance metrics and enables secure multicolor recognition for next-generation encrypted communications.

Stable solid electrolyte interface (SEI) is heavily investigated due to its role in improving lithium metal batteries. Here, the authors present a new strategy by employing electrolyte additives to construct stable multifunctional SEI via in situ anionic polymerization.

This work presents a far-field femtosecond laser patterning method to fabricate super-resolution nano-groove array structures in 2D multilayer NbOI2 in ambient air, with groove widths as low as ~14.5 nm ( ~ λ/73).

Structural instability is a major drawback of high-capacity lithium-based battery cathodes. Here, the authors report a cathode active material with a medium-entropy state created by partial cation disordering capable of restraining the structural evolution in the high-capacity operated spinel phase.

Porous solids have potential applications in energy storage, gas separation and catalysis technologies. Here, the authors report a hierarchical solid with porosity spanning the micro, meso and macro ranges, which is synthesized using templating silica, and potassium ions as both templates and reactive species.

The burst release of annexin A5 from intravenously injected nanoparticles that rapidly degrade in tumours generates robust anti-tumour immunity by shifting late-stage immunosuppressive apoptosis to immunostimulatory necrosis.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

Copolymerization with cleavable comonomers is a versatile approach to generate vinyl polymer with a viable end-of-life option. Here, the authors show that an anion binding catalyst seleno cyclodiphosph(V)azanes enables the efficient cationic copolymerization with cyclic acetals by reversibly activate both different dormant species to achieve both high living chain end retention and high molecular weight.

Characterization of the genetic architecture underlying the 7 pairs of contrasting traits studied by Mendel and the over 70 additional agronomic traits in pea (Pisum sativum) reveals their molecular details and provides tools for further studies in pea genetics, functional genomics and crop improvement.

Sustainable harvesting of lithium is critical to the success of the entire battery industry. Here, the authors report an electrochemical leaching method which can directly extract lithium from natural state spodumene ores with low energy consumption, environmental impact, and high efficiency.

High-voltage non-aqueous lithium metal batteries suffer from poor cycling stability due to the presence of impurities in the electrolyte solution. Here, the authors report lithium hexamethyldisilazide to scavenge HF and H₂O, prevent the Ni dissolution and suppress side reactions during cycling.

Lithium carbonate-promoted mixed rare earth oxides can be used as redox catalysts for OCM at 700 °C and achieve a single-pass C2+ yield up to 30.6%. The high activity is assigned to the peroxide and OH radicals induced by Pr⁴⁺ in the redox catalyst.

The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.