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Electrification is a promising way to decarbonize the chemical industry but could also have important effects on power systems. Here the authors assess the impact of electrifying the production of methanol and ammonia on the Chinese power system in terms of emissions and potential security risks.

X chromosome inactivation (XCI) is crucial for gene regulation, yet the role of small non coding RNAs in this process was unclear. Here, the authors identify miR106a as a key XCI regulator and show its inhibition improves Rett syndrome symptoms in a mouse model.

A collagenase nanogel backpack enhances CAR-T cell therapy in pancreatic cancer by improving cell infiltration and overcoming physical barriers, enabling potent tumour regression and prolonged survival.

Regioselective functionalization of aliphatic carbon–hydrogen bonds is achieved using frustrated radical pairs generated from disilazide donors and an N-oxoammonium acceptor.

An electrochemical strategy is described in which the direct carboxylation of pyridines and related N-heteroarenes with CO₂ shows divergent site selectivity depending on the type of reactor used.

The authors introduce a loss-enhanced magneto-optical effect and sublinearly amplify the frequency response of a non-Hermitian optical cavity under different background magnetic fields. This effect is exploited to detect subtle magnetic field variations against a strong background with enhanced system response and sensitivity.

The authors reveal hyperbolic-to-hyperbolic transitions where two nearby Reststrahlen bands just touch each other. Such phenomena are prevalent in isostructural rare-earth oxyorthosilicates and unfolds vast opportunities for broadband on-chip light control.

Owing to strong Coulomb interactions, atomically thin transition metal dichalcogenides host strongly bound excitonic complexes. Here, the authors report charge-neutral biexciton and negatively charged trion-exciton complexes in hBN encapsulated monolayer WSe₂ by employing low-temperature photoluminescence spectroscopy.

Selective catalytic oxidation (SCO) of NH₃ to N₂ is a highly effective approach for reducing NH₃ emissions, though achieving high conversion across a broad temperature range without over-oxidation to NOx remains challenging. Here, the authors introduce a bi-metallic surficial Pt-Cu catalyst that effectively removes NH₃ from both stationary and mobile exhaust sources via SCO.

Aliphatic C–H functionalization is a valuable tool in organic synthesis. Now a hypervalent iodine reagent has been shown to release a potent hydrogen atom abstractor for C–H activation under mild photochemical conditions. This enables the transformation of C–H bonds into diverse functional groups with tunable control over the site selectivity.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

An out-of-plane magnetic field is expected to strongly modify exciton-phonon interactions in atomically thin transitional metal dichalcogenides. Here, the authors show that the phonon-exciton interaction in monolayer WSe₂ lifts the inter-Landau-level transition selection rules for dark trions.

A systematic design of light-absorbing molecules is challenging for them to satisfy multiple key requirements for efficient solar cell application. Here, the authors optimize halogen substitution position in terminal groups of acceptors for realizing ternary cells with efficiency approaching 20%.

Mutations in WDR62 are the second most common genetic cause of autosomal recessive primary microcephaly, yet the molecular mechanisms underlying this pathogenesis remain unclear. Here, authors demonstrate that WDR62 depletion leads to neural precursor cell depletion and microcephaly via WDR62-CEP170-KIF2A pathway that promotes cilium disassembly.

The communication of colour information stands as one of the most immediate and widespread methods of interaction among biological entities. Xu et al. report an electrochromic neuromorphic transistor employing color updates to represent synaptic weight for real-time visualised in-sensor computing.

Acute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals and appropriate controls, that human T cell lymphotropic virus type I infection of donor immune cells appear to correlate with the occurrence of acute graft versus host disease.

The long lifetime and spin properties of dark excitons in atomically thin transition metal dichalcogenides offer opportunities to explore light-matter interactions beyond electric dipole transitions. Here, the authors demonstrate that the coupling of the dark exciton and an optically silent chiral phonon enables the intrinsic photoluminescence of the dark-exciton replica in monolayer WSe₂

Photoelectrochemical oxidation of glycerol to produce dihydroxyacetone is limited by its low selectivity. Here, a bismuth vanadate photoanode enriched with a bismuth-rich surface and containing oxygen vacancies was utilized to overcome this dilemma.

Magnetic phases that are stabilized by quantum fluctuations in low dimensions are rare. A thickness-dependent crossover from three-dimensional antiferromagnetism to a two-dimensional vestigial nematic state that is driven by fluctuations has now been observed.

Modulating single-metal sites at the atomic level can boost the intrinsic catalytic activity. Here, the authors describe the design of Pt atomic clusters containing Pt-O-Pt units supported on Co single atoms and N co-doped carbon for enhanced hydrogen evolution catalysis.

Separation of actinides from lanthanides is very important for the safe management of nuclear waste, however still challenging due to the chemical complexity of the f-elements. Here, authors report an efficient strategy with graphene oxide membranes for ion sieving of high valent actinyl ions and spherical lanthanide ions.

Previously, the small molecule inhibitor of transcriptional enhanced associate ___domain (TEAD) MGH-CP1 has been described in stem cells. Here, the authors demonstrate the utility of MGH-CP1 in cancer therapy and find treatment to increase Akt pathway activation via TEAD-Vgll3 activation, presenting a rationale for combination with Akt inhibition.

A method is reported that produces highly strong, tough and elastic 2D COF films, using a sacrificial go-between, which endows them with new properties, enhances their current applications and paves the way for new applications.

Determination of RNA 3D structures in vivo is a challenging problem. Here, the authors describe a chemical crosslinking method (SHARC) that they use in combination with RNA sequencing to measure distances between nucleotides in RNA 3D structures.

The ploidy level of patchouli, an aromatic plant in the Lamiaceae family, remain unclear. Here, the authors assemble a chromosome-level and haplotype-resolved genome for patchouli and reveal that it is tetraploid hybrid as well as compensated aneuploidy.

The photocatalytic decarboxylation of fatty acids affords alkanes under mild conditions, albeit with limited selectivity due to radical-mediated side reactions. Now, a hydrogenated Pt/TiO₂ catalyst is introduced for the selective conversion of C₁₂–C₁₈ fatty acids into C_n–1 alkanes in quantitative yields.

Current industrial production of hydrogen peroxide suffers from hefty energy penalties and toxic byproducts. Here, the authors report efficient photocatalytic production of hydrogen peroxide by protonation-induced dispersible porous polymers with good charge-carrier transport properties.

Robust, fast, and low-power hardware platforms are desirable for the implementation of real-time machine vision. Here the authors develop a computing-in-sensor network using ferroelectric photo sensors with remanent-polarization-controlled photo responsivities.

A variety of signals have been reported to either activate or inhibit the Hippo kinase cascade. Here, Meng et al. show that mitogen activated protein kinase kinase kinase kinase (MAP4K) family members function in parallel to and are partially redundant with MST1/2 in regulating LATS in response to upstream signals.

The authors present ARPES and STM/STS measurements of the kagome superconductor CsV_3-xTa_xSb₅. For the x = 0.4 Ta-doped sample, they report evidence for a van Hove singularity perfectly aligned with the Fermi level, and that the superconducting transition temperature is maximized at this doping.

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

The long noncoding RNA XIST plays a central role in sex-specific gene expression in humans by silencing one of two X chromosomes in female cells. Here the authors show that higher order secondary structure creates the modular ___domain structure of XIST ribonucleoprotein complex and spatial separation of functions.

RNA crosslinking and proximity ligation methods are used to identify transcriptome-wide base pairing interactions. Here, the authors report PARIS2 (psoralen analysis of RNA interactions and structures 2), a method for RNA duplex determination in vivo with higher efficiency than the previous PARIS method.

To keep radiation therapy from damaging healthy tissue, expert radiologists have to segment CT scans into individual organs. A new deep learning-based method for delineating organs in the area of head and neck performs faster and more accurately than human experts.

Characteristics of spin waves in recently discovered two-dimensional (2D) Ising ferromagnets are still lacking. Here, Jin and Kim et al. report Raman resonance evidence of two sets of surface spin waves in the 2D honeycomb ferromagnet CrI₃.