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The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the phosphoglucose isomerase gene PGI1, and engineering a synthetic energy system to regulate NADH/NAD⁺ ratio.

Effects of snow cover dynamics, land use or land cover conversions and non-conversion regions on albedo variations during 2001–2020 are quantified and their induced radiative forcing estimated, highlighting the role of land surface dynamics in modulating global warming.

The H+CH₄substitution reaction is the simplest reaction occurring via the Walden inversion mechanism. Here, the authors perform a theoretical study of the reaction and uncover the important effect of the umbrella motion of the non-reacting methyl group on the reaction dynamics.

The formation of directional fibrous tissue bands, typical of liver fibrosis progression, might be induced by the tension of the hepatic stellate cells, as studied with an in vitro microfabricated model.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Single-atom and nanocluster catalysts have been widely studied in heterogeneous catalysis, yet their coexistence and potential synergistic effects remain unclear. Here, the authors investigate atomic-scale Ni-based catalysts for bioethanol reforming and reveal a synergistic interaction between single atoms and nanoclusters.

A telomere-to-telomere genome assembly of the elite Gossypium hirsutum variety ZM113 provides insights into upland cotton short-season adaptation and identifies a repositioned, satellite repeat-rich centromere.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

A small-molecule agonist of transient receptor potential cation channel subfamily M member 4 persistently activates the ion channel and induces necrosis characterized by sodium overload.

Machine-learned potentials are accurate but often lack broad applicability. Here, authors develop a general-purpose neuroevolution potential for 16 metals and their alloys, achieving efficient and accurate predictions of various physical properties.

Here, the authors develop a plasmon-free SERS platform based on two-dimensional MnPS₃ with sub-attomolar detection limit. Their strategy is based on a mechanochemical approach that combines wrinkling and chemical functionalization to boost SERS performance, making it relevant for biosensing.

Using a combination of antibody- and LC–MS/MS-based methods, Zhang et al. reveal lysine l-lactylation as the key lactylation isomer in cellular histones, responding dynamically to glycolysis and positively correlating with lactyl-CoA levels, providing insights into the Warburg effect.

Developing heat-resistant dielectric polymers for electrification is challenging due to the inverse relationship between thermal stability and electrical insulation. Using a machine learning-driven approach, the researchers identify and validate high-performance polymers that demonstrate promising thermal resilience and energy density for high-temperature applications.

Authors develop a siRNA delivery system, named Ionizable Polymeric Micelles (IPMs) which employs a FAPi modification, enabling IPMs to target activated hepatic stellate cells, silencing target genes and treating liver fibrosis.

Wide use of graphene nanosheets has raised concerns about the potential for environmental toxicity. Here, the authors explore the use of humic acid, traditionally considered to reduce graphene nanosheet toxicity, and show the coating has increased toxicity to model bacteria.

Sn doping enables a breakthrough in p-type AgSbTe₂ for thermoelectric applications, achieving a zT of 2.5 and 12.1% device efficiency. The authors reveal an impurity band mechanism, offering a strategy for AgSbTe₂ optimization.

Metabolic dysfunction-associated steatohepatitis (MASH) poses challenges for targeted delivery and retention of therapeutic proteins due to excess extracellular matrix (ECM). To address this, the authors developed a “Fibrosis Overexpression and Retention (FORT) strategy” that can improve mRNA expression in the fibrotic region and extend the expressed protein in situ.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

Using deep brain stimulation of the habenula with implanted electrodes in patients with treatment-resistant depression, this study found a substantial reduction in depression scores at follow-up over multiple time points.

A new class of miRNA-recognition elements that function exclusively in protein-coding regions use distinct target-recognition rules and mediate translational repression instead of mRNA destabilization.

Hydrogenolysis of waste polyolefins often produces excessive methane under low hydrogen pressure. Here, by using a dilute RuPt alloy, the authors successfully prevent sequential C–C bond cleavage, enabling flexible use of various hydrogen sources for localized plastic recycling.

In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

Li et al. perform a phase 2 single-arm clinical trial of neoadjuvant chemotherapy plus checkpoint blockade in participants with resectable muscle-invasive bladder cancer and conduct genomic and transcriptomic profiling to describe molecular subtypes.

A fluorescent nanoprobe that amplifies the fluorescent signal in a broad range of tumours allows for real-time tumour-acidosis-guided detection and surgery of occult, less-than-1-mm³ nodules in mice bearing head and neck or breast tumours.

Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide but current drug therapeutics show important limitations. Here, the authors exploit a selfpropelling nano-penetrator with high fuel loading and controllable motion which is molecularly co-assembled using a photothermal photosensitizer and a photothermal-activable NO donor.

Metals supported on metal oxides are common heterogeneous catalysts. Here the authors show that metal/oxide interfacial sites are highly active for alcohol oxidation—independent of the particle sizes—and use this information to design inverse oxide-on-metal particles with high activity and stability.

Yao Zhao, Yongyong Shi and colleagues performed a genome-wide association study on sporadic pituitary adenoma in the Han Chinese population. They identify three new susceptibility loci.

This work reports a facile method for growing highly ordered Pt and Mn bimetallic single atomic layers on graphdiyne. This fully activates loaded metal atoms and results in in high activity and selectivity for electrocatalytic alkene-to-diol conversion

The development of robust quasi-ohmic contact with minimal resistance, exceptional stability and cost-effectiveness is crucial for practical application of perovskite solar cells. Here, authors report a polymer-acid-metal structure as the contact and realize long photo-thermal-operational stability.

Incorporation of a ‘liquid diode’ into a wearable electronic platform enhances comfort and stability by shunting away sweat as it accumulates.

State-of-the-art electrolytes limit the cycle life of halide-ion batteries. Here, the authors report a fluorinated low-polar gel polymer electrolyte capable of improving the stability of the electrolyte and electrode interphases to boost battery performance.

The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.

Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic ___location and patterns of introgression consistent with multiple rice domestication events.