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The authors develop a low carbon cement-based material which exhibits hierarchical structure with low density (0.75 g cm⁻³), high specific compressive strength (344 (kN m⁻²)/(kg m⁻³)) and fracture toughness (4865 kJ m⁻³).

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

Loss of the tumor suppressor PTEN is often observed during endometrial cancer (EC) progression. Here the authors show that the deacetylase SIRT7 mediates PTEN deacetylation in an estrogen-dependent manner, leading to increased ubiquitination and degradation of PTEN to promote EC metastasis.

Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia/reperfusion injury.

The reaction types of photoelectrocatalytic organic synthesis (PECOS) are limited to simple oxidation and C–H activation at current stage while metal catalysis for the construction of C(sp2)–N bonds remains unexplored. Here, the authors introduce a PEC method that successfully engages Ni catalysis for the mild production of aniline derivatives.

The development of artificial vision for blind people has been a long-standing endeavour. Tang et al. create a wearable multimodal visual assistance system with a human-centred design, blending software and hardware innovations to enhance usability.

The discovery of the resistosome was a milestone in plant immunity. Here, Zhong et al. identify a kinase that phosphorylates the NLR, and reveal how this kinase regulates resistosome assembly to fine-tune immune responses.

Rare particle enrichment is vital for research and industry. Huasheng Zhuo and colleagues introduce a microfluidic system combining acoustic, optical, and electrical units, achieving advancements in detection sensitivity and manipulation accuracy.

Enantioselective substitution reactions of racemic alkyl halides are inherently limited by the specificity of their stereochemical course (S_N1 or S_N2). Here, the authors report a radical coupling strategy for the enantioselective aminoalkylation of α-bromoketones for modular, highly enantioselective C_sp3−C_sp3 bond formation.

Carbohydrates are essential for regulating various biological processes. Here, the authors developed DeepGlycanSite, a deep learning model that accurately predicts carbohydrate-binding sites on proteins, offering insights into carbohydrate regulation of therapeutically important proteins.

A biomimetic electrochemical eye is presented that has a hemispherical retina made from a high-density array of perovskite nanowires that are sensitive to light, mimicking the photoreceptors of a biological retina.

Sun et al. identify the deubiquitinase USP15 as a regulator of PARP1 stability in triple-negative breast cancer and show that the hormone receptors ER, PR and HER2 inhibit USP15-mediated PARP1 stabilization, modulating base excision repair.

Tungsten trioxide (WO₃) is considered the most promising photocatalyst for the highly selective oxidation of methane to formaldehyde, though the origins of its catalytic activity and reaction mechanism are still debated. Here, the authors use WO₃ with {001} and {110} facets as model photocatalysts, demonstrating that the photocatalytic oxidation of methane to formaldehyde in WO₃ depends on the surface structure, leading to different formaldehyde selectivity.

Zhen and colleagues show that nuclear cGAS represses L1 retrotransposition to stabilize the genome by enhancing the interaction between ORF2p and the E3 ligase TRIM41 upon DNA damage, which leads to the ubiquitination and degradation of ORF2p.

van der Waals heterostructures and superlattices are interesting due to their emerging physical properties, but they are usually fabricated via complex top-down methods. Here, the authors report a chemical vapor transport method to synthesize NbSe₂-based 1T/1H superlattice single crystals, showing hybridized electronic properties from the constituent layers.

Due to their dynamic planar chirality, pillar[n]arenes are promising circularly polarized luminescence emitters but efficient solution state emission is a challenge due to the unit flipping and swing. Here, the authors report a mechanically locking approach for boosted dissymmetry factor values of pyrene-tiaraed pillar[5]arenes up to 0.015 through the formation of corresponding [2]rotaxanes.

Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.

Besides device operational stability, the color stability is also an important challenge for the perovskite light-emitting diodes, especially the blue ones. Here Jiang et al. report the most efficient and color stable pure-blue perovskite LEDs so far, with a half-lifetime of 14.5 minutes.

Species responses to climate change may be challenging to predict. Here, the authors demonstrate the value of combining genomics, niche modelling, and landscape connectivity to estimate population-level vulnerability under future climate scenarios in two bird species.

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

Chiral interaction of molecular ensembles with confined light fields is elusive. Here, the authors report collective chiroptical effects through coupling of exciton and charge-transfer mixed molecular assemblies with plasmonic nanoparticles.

The second Global Amphibian Assessment finds that the status of amphibians is continuing to deteriorate globally, driven predominantly by climate change, disease and habitat loss.

Changes in continental water storage have been difficult to constrain from space-borne gravity data in regions experiencing both ice melting and glacial isostatic adjustment. Separation of the hydrologic and isostatic signals reveals increases in water storage in both North America and Scandinavia over the past decade.

Bound states in continuum have attracted attention in various platforms, and recently condensation of bound states in continuum polariton modes was demonstrated at low temperatures. Here the authors report the observation of such a state in a periodic air-hole perovskite-based photonic crystal at room temperature.

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

Carbon nanotube networks made with high purity and ultraclean interfaces can be used to make a tensor processing unit that contains 3,000 transistors in a systolic array architecture to improve energy efficiency in accelerating neural network tasks.

Redox imbalance limits succinic acid (SA) biosynthesis from glucose via the reductive tricarboxylic acid (TCA) cycle in yeast. Here, the authors engineering the aerobic yeast Yarrowia lipolytica for efficient SA production without pH control via coupling the oxidative and reductive TCA cycle for NADH regeneration in mitochondria.

While significant progress has been made in classical Diels-Alder reactions, the use of simple and inert feedstock chemicals under mild reaction conditions still remains challenging. Here the authors present the development of catalytic asymmetric [4 + 2] dearomative photocycloaddition involving anthracene and its derivatives with alkenylazaarenes.

Zhang et al. report that a non-canonical cGAS–STING pathway activates PERK–eIF2α to elaborate cap-dependent mRNA translation and contributes to senescence and fibrosis.

The redox properties of visible-light-absorbing photosensitizers are limited by the energy of visible photons, but methods using sensitization-initiated electron transfer have recently been developed to address these challenges. Now a multiphoton dual-catalyst strategy has been used to enable the enantioselective de Mayo reaction for the synthesis of enantioenriched 1,5-diketones.

Development of high-performance, comfortable and sustainable air filters is challenging. Here, authors design an ultrathin, ultralight dual scale fiber mat composed of true nanofibers and submicron-fibers to integrate the high protection, thermal wet comfort and save raw materials.

Chrysanthemum is an important ornamental species with great economic value. Here, the authors assemble the haploid genome of C. morifolium, reveal its segmental allopolyploid genomic composition (AA’B), and identify candidate genes associated with flower development, petal shape, and flower colour.

Locusts are destructive agricultural pests and serve as a model organism for studies of insects. Here, the authors report a draft genome sequence of the migratory locust, Locusta migratoria, and provide insight into genes associated with key survival traits such as phase-change, long-distance migration and feeding.

This study analyses radio observations of the jet in galaxy M87, from which the existence of a spinning black hole that induces Lense–Thirring precession of a misaligned accretion disk is inferred.

TIP60-mediated crotonylation of the microtubule plus-end tracking protein EB1 at Lys66 regulates attachment of astral microtubules to the lateral cell cortex and spindle positioning.

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

J-aggregation has been proved to be an efficient strategy for the development of fluorescent imaging agents in the NIR-II spectral region but the design of appropriate J-aggregates is challenging. Here, the authors demonstrate J-aggregation of a BODIPY dye with NIR-II emission and demonstrate lymph node imaging for fluorescence guided surgery.

Food safety is jeopardized by the global trade in contaminated foods. Huang et al. demonstrate how consumer exposure to the toxic chemical polychlorinated biphenyl-153 (PCB-153) can be modelled and identify regions with high consumer PCB-153 exposure resulting from imported fish consumption.

Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases.

Mudskippers are amphibious fishes that have adapted to live on mudflats. Here, the authors sequence the genomes of four different mudskipper species and highlight genetic changes that may have had an evolutionary role in the water-to-land transition of vertebrates.