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Photovoltages generated from semiconducting single-walled carbon nanotubes are often too small for most practical solar-energy-harvesting applications. Here, researchers demonstrate that virtual contacts can be used to multiply photovoltages from around 0.2 V to 1.0 V.

The practical application of solid-state rechargeable alkali metal batteries is hindered by the poor contact between the metal electrode and the solid electrolyte. Here, the authors report an ultrasound solid welding strategy to favor the contact between these cells components.

Organic two-dimensional crystals represent a versatile toolkit for exploring intriguing electronic and quantum phenomena. This Review discusses the structure–property relationships and synthetic methods of these materials, highlighting their electronic and quantum properties and emerging device applications.

Here, the authors apply the Activity-by-Contact (ABC) model to infer enhancer-gene regulation and the effect of associated variants across multiple cancer types, integrating genetic and multi-omics data. Then, they explore the mechanisms associated with ABC regulatory variants in colorectal cancer.

Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of the mature virus and natural empty particles reveals that the larger empty particles resemble elusive enterovirus uncoating intermediates, allowing insight into the process of enterovirus uncoating.

This paper presents FpClass, a prediction method for physical protein-protein interactions. The method is benchmarked against experimental data and is used to predict, among others, partners of interactome 'orphans'.

Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effect.

Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.

Cao et al. reports highly efficient, flexible, and larger-area Red/Green/Blue perovskite light-emitting diodes based on all-inorganic metal halide perovskite quantum wires arrays fabricated by porous alumina membranes assisted solution method.

A recent study using genomic modelling has uncovered the complex population history of wheat in the Holocene, identified convergent adaptation during bread wheat’s spread across Eurasia and predicted future population decline of its key relatives.

Hippo TEAD-transcriptional regulators YAP1 and TAZ modulate cell growth, but the downstream networks are unclear. Here, the authors use a genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) to disrupt transcriptional networks for cell cycle and terminal differentiation in human keratinocytes and mouse skin.

The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.

Spiders use self-produced venom and silk for their daily survival. Here, the authors report the assembled genome of the social velvet spider and a draft assembly of the tarantula genome and, together with proteomic data, provide insights into the evolution of genes that affect venom and silk production.

Jianquan Liu and colleagues report the draft genome sequence of the domestic yak, Bos grunniens. Their comparative analyses with low-altitude cattle provide insights into high-altitude adaptation in the yak.

A domestication strategy to cultivate efficient and resilient functional microbiome for addressing phenolic wastewater challenges sheds light on the artificial construction of microbiome for the engineering application of treating industrial wastewater.

Cation exchange membranes embedded with MnO₂ nanoparticles form selective outer-sphere complexes with phosphate ions imparting an extremely selective permeation pathway.

Self-secondary impact craters are rare on Mars relative to airless bodies and are almost absent in layered ejecta deposits, according to satellite observations of Martian surface geology which suggest the two deposit types form largely contemporaneously.

Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue. Authors here dissect the function of IL18 signalling in the adipose compartment by targeted genomic deletion of its two receptors individually and in combination in brown and white adipose tissues.

Response rates to immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) remain low. Here the authors show that ablative treatment of tumor-draining regional lymphatics, a standard of care approach in patients, impairs the tumor response to ICI in preclinical HNSCC models.

The water surface has recently proven to be an effective platform for the synthesis of large-area two-dimensional polymers with high crystallinity. Here, the authors report the on-water synthesis of a crystalline monolayer 2D polyimide, as well as its incorporation into organic–inorganic hybrid van der Waals heterostructures that display significant charge transfer and high electron mobility.

Grain boundaries in graphene degrade its properties, and large single-crystal graphene is desirable for electronic applications of graphene. Gaoet al. develop a method to produce millimetre-sized hexagonal single-crystal graphene grains, and films composed of the grains, on platinum by chemical vapour deposition.

Bats account for 20 per cent of all mammals, these are the only mammals with powered flight, and are among the few animals that echolocate. Here, Seim et al. sequence the genome of the long-lived (>40 years) Brandt’s bat, Myotis brandtiiand provide clues to its evolution, longevity and other traits.

Membranes with high selectivity and high permeance that allows rapid passage of solvent molecules are desirable for efficient separation processes. Microporous conjugated-polymer membranes have now been fabricated through surface-initiated polymerization. These membranes are capable of ultrafast organic-solvent nanofiltration because of the high porosity and pore interconnectivity originating from the rigid skeleton.

The ferromagnet CeRh₆Ge₄ is found to exhibit strange-metal behaviour at a quantum critical point, suggesting that changes in the pattern of quantum entanglement, not antiferromagnetism, underlie the development of strange metals.

Two-dimensional (2D) membranes are emerging candidates for osmotic energy conversion but the trade-off between ion selectivity and conductivity remains the key bottleneck. Here, the authors demonstrate a fully crystalline imine-based 2D polymer membrane capable of combining excellent ionic conductivity and high selectivity for osmotic energy conversion.

The ultrathin thickness, high pore density and short interpore distance of a COF monolayer endow an extremely low membrane resistance and strong pore–pore coupling, which greatly improves the membrane-based osmotic power generation.

The use of perovskite quantum-wire light emitters results in high-quality planar and spherical light-emitting diodes.

Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated to MMAE promote anti-tumor immune responses, improving response to checkpoint inhibitors in preclinical cancer models.