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This study reports the design of heterogated nanoprobes for interval-based pH imaging in biological systems, including cellular endocytic organelles and tumours. The modular design allows for fine-tuning of pH transition point and fluorescent emission.
This is a protocol for the synthesis of ultrasound-sensitive probes that emit sonoafterglow with bright near-infrared emission that are suitable for the deep-tissue imaging of peroxynitrite, a biomarker for M1 macrophages and proinflammatory microenvironments.
Organic phosphorescence materials offer advantages for bioimaging applications, but most of them are excited exclusively by ultraviolet light, which poses risks to living organisms. Here, the author report doped materials with white-light activated phosphorescence activity, and a bioimaging mode in which these phosphorescent materials are first concentrated within the organism and then excited.
Nanocrystals are synthesized with long-term colloidal stability in both polar and non-polar solvents without the need for ligand exchange. During synthesis, conventional coordinating ligands and solvents with long alkyl chains are replaced with those bearing alkoxy repeating units.
We have discovered an effect, termed stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS), that enhances the Raman signal intensities of small molecules by relying on their self-stacking rather than external substrates. This effect enables the design of substrate-free small-molecule probes for high-resolution, non-invasive transdermal Raman imaging of lymphatic drainage and microvessels.
Biomineralization approaches have been used for the synthesis of nanoparticles. Here, the influence of nucleation sites and protein size on the production of iron oxide nanoparticles for magnetic resonance imaging applications is described.
A nanosensor probe that combines a tumour-targeting peptide, a diagnostic reporter and an imaging contrast agent enables early diagnosis, precision imaging, disease stratification and downstream therapeutic response monitoring of metastatic cancer.
