Extended Data Fig. 4: P-amylase (a) and lipase (b) levels over time.

Data presented are estimate mean (SE). Error bars indicate SE. Baseline values were calculated using an ANOVA, post-baseline measures were calculated from an MMRM, all statistical tests were two sided at a significance level of 0.05. Normal reference values: p-amylase (13–53 IU/L); lipase (13–60 IU/L). ANOVA, analysis of variance; MMRM, mixed model for repeated measures; No., number of patients with baseline and post-baseline value at the specified time point; p-amylase, pancreatic amylase; TZP, tirzepatide; SE, standard error; SFU, safety follow up.