Extended Data Fig. 3: NMF metaprograms.
From: Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases
a, Gene set enrichment analysis indicating cancer hallmarks and gene ontology signatures enriched in each of the 8 metaprograms identified by NMF. Q score is FDR adjusted p-value. b, Expression of mixed PT/BM MP signatures (MPs 1, 2, 3, 6) across healthy and malignant tissues (normal lymph node, normal lung, pleural effusion, early/late stage lung cancer, lymph node metastases, and BMs) profiled in Kim et al 202012. Upper and lower edges of boxplots indicate 75th and 25th percentiles, respectively, and middle line indicates median. Tails extend to the 95% confidence interval. Statistical test and significance level as indicated on each boxplot.
