Fig. 5: Caveolae integrate DMT1, NKA and NCX.
From: Iron induces two distinct Ca2+ signalling cascades in astrocytes
a Representative protein western blot bands for DMT1, NCX1-3 and NKA-α1/α2 in caveolae membranes extracted from cultured astrocytes. Astrocytes were treated with sham (Control), with siRNA negative control (−) or with Cav3 duplex chains (siRNA(+)) for 3 days. b Protein levels are shown as the ratio of DMT1 (55 kDa) and β-actin (42 kDa), NCX1 (108 kDa) and β-actin, NCX2 (102 kDa) and β-actin, NCX3 (100 kDa) and β-actin, NKA-α1/α2 (100 kDa) and β-actin (42 kDa). Data represent mean ± SD, n = 6. *Indicates statistically significant (p < 0.05) difference from any other group; **indicates statistically significant (p < 0.05) difference from control plus Fe2+ group or Cav3 siRNA(+) plus Ctrl group.
