Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This study presents cryo-EM structures of H4R–Gi and H1R–Gi/Gs complexes, revealing distinct histamine recognition, activation mechanisms, and a critical determinant of G protein selectivity in H1R and H4R.
The My Baby Biome Study demonstrates that three gut microbiome community clusters exist in infants in the United States. These compositions vary on the prevalence and abundance of Bifidobacterium and impact risk for the development of atopic disease.
A transcriptome atlas of Xenopus tropicalis reveals the role of the immune-reproductive trade-off mediated by metabolic reprogramming in maintaining homeostasis from the perspective of inter-organ crosstalk.
Spatial connectivity between kelp forests and sandy beaches, in terms of kelp subsidies, is highly localized and primarily dependent on kelp canopy biomass. However, attributes of the beach including width and orientation are also important.
Distinct hippocampal-cortical systems support the encoding and sequencing of narrative events during ongoing comprehension, revealing how episodic memory integrates past and present information into coherent narratives.
Mycobacterium tuberculosis (M.tb) infection of human alveolar macrophages reveals a variably expressed gene network with inter-individual variability, guiding future studies to determine individual risk of M.tb infection and tuberculosis disease.
Transcriptional analysis of lipid associated macrophages across chronic inflammatory diseases and tissues reveals shared and tissue-restricted gene expression programs.
This study provides key mechanistic insights into how direct coupling of ECM to actin through talin has specific and critical roles in controlling adhesion dynamics required for early mammalian development.
Profiling crRNAs revealed optimal length for Cas12-based molecular testing and SNP detection. Investigation into multivalent architectures elucidated valency and distance dependence for synergistic Cas12 activity.
SMODEL integrates spatial multi-omics data through dual-graph-regularized ensemble learning to robustly detect spatial domains, revealing tissue architecture and cellular heterogeneity.
Exercise can increase the expression of microglial ceramide synthase 1 (CerS1), regulates sphingolipid metabolism, and improves depressive-like behaviors in adolescent mice.
Physics-based modeling of translation elongation in E. coli reveals the mechanistic role of L12 stalks in pre-loading the ribosome to speed translation.
A neuroimaging tool, TACOS, was developed to transform network-based statistics across brain structural and functional networks from different atlases. Using TACOS, connectomic findings could be easily combined or compared without handling raw data.
High-speed and high-sensitive three-dimensional immunohistochemistry by using peroxidase-fused nanobodies and a tyramide signal amplification system, Fluorochromized Tyramide-Glucose Oxidase.
Overgrowth of cellular microtubules (MTs) is associated with a range of disease processes. Cellular and biophysical reconstitution experiments reveal that estradiol transforms dynamic, growing MTs into paused, non-growing MTs.
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase and 2 nM sensitivity for IL-6.
Watmuff et al. show that drug treatments like carbamazepine reduce hyperactivity and improve goal-directed performance in a neural microphysiological system (DishBrain), suggesting its potential for studying drug effects on information processing.
A robust in vivo method for engineering plasmid DNA in E. coli using a triple-selection system that works at any copy number, enabling fast, scalable construction of standardized plasmids for synthetic biology applications.
