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Sperm navigate the human Fallopian tube by three distinct processes. While their behavioral mechanisms are known, their molecular basis is gradually being uncovered. These processes can improve in vitro fertilization outcomes in clinical settings.
Palaeo-bioinspiration greatly increases the potential of nature-inspired innovation by incorporating extinct biodiversity, which represents 99.9% of all life on earth.
A review summarizes how progranulin (PGRN) regulates lipid metabolism, dysregulation of which contributes to neurodegeneration. Hence, PGRN represents a promising therapeutic target for restoring lipid homeostasis and mitigating neurodegeneration.
A review summarizes the interplay of the lung microenvironment in metastatic osteosarcoma in human and canines, including immune and resident lung cells, and how this knowledge can inform treatment for both patient populations.
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility.
This perspective highlights spatially restricted coral bleaching as an underexplored ecological phenomenon that offers critical insight into within-colony heterogeneity.
This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs.
This review surveys the core metabolic fluxes employed by sebaceous glands to achieve sebum synthesis and examines the idea that metabolic-driven processes are an important mechanistic component of holocrine secretion.
A review summarizes the current understanding of the complex molecular pathways mediating plant responses to multiple abiotic stresses, and discusses current and future challenges and unanswered questions.
A review on the implementation of proximity-dependent biotin identification (BioID) in the study of host-microbe interactions mediated by bacteria discusses advances in BioID that may benefit future host-microbe interactions research.
Archaeal research and its growing importance have benefited from a community that is engaged in various collaborative efforts, which are highlighted here with examples for the sharing of resources and data, as well as the building of supportive environments to advance the community.
The contribution of peripheral tissue clocks to the maintenance of metabolic homeostasis, and their importance in shift work-associated metabolic disease
Removal of sharks and large teleosts by fishing creates a trophic cascade by altering anti-predator behaviors of mesopredatory fishes, which reduces predation on Crown of Thorns Starfish, allowing the species to form outbreaks on coral reefs.
A review examines how quorum sensing, a bacterial communication system, shapes marine eukaryote interactions, influencing processes such as development, disease pathogenesis, and microbiome regulation within marine ecosystems.
This review highlights current knowledge and recent advances regarding P4-ATPases, focusing on substrate diversity, regulation of cellular localization, enzymatic activities, and their impact on organism homeostasis and diseases.
By highlighting recent advancements in the understanding of circRNA-protein interactions, this review discusses their implications in cancer therapy and drug resistance mechanisms.
Virome-scale studies are changing our understanding of the virosphere, but deficiencies in reporting may limit the value of these studies. To increase the usefulness of virome-scale studies, 10 recommendations for the improvement of reporting are provided.
This review on soil restoration in agricultural systems suggests comprehensive restoration actions harnessing the interdependence of multiple soil properties, including contribution to vegetative yield, to be most efficient in agricultural settings.
This review highlights the cellular and molecular mechanisms in which ROS are involved in normal wound healing and chronic wound pathogenesis, as well as recent advances in therapeutic methods.
