Fig. 4: Activation induced TIGIT expression is specific in Tfh cells. | Communications Biology

Fig. 4: Activation induced TIGIT expression is specific in Tfh cells.

From: Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells

Fig. 4

a Representative flow cytometry plots divided into CD45RA and CXCR5 staining of CD4+ T cells from HCs, and TIGIT and PD-1 expression in each divided subset is shown. b–e Each divided subset sorted from healthy donors (n = 3) and stimulated with anti-CD3/anti-CD28 beads. Samples were collected at the indicated time points, and TIGIT (c) and PD-1 (d) expression, and each mean fluorescence intensity (MFI) (e) (mean ± SEM) were assessed using flow cytometry.

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