Fig. 7: Anti-human-TIGIT agonistic mAb (αTIGIT) regulates T cell imbalance in autoimmune states. | Communications Biology

Fig. 7: Anti-human-TIGIT agonistic mAb (αTIGIT) regulates T cell imbalance in autoimmune states.

From: Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells

Fig. 7

a TIGIT expression is upregulated by T cell stimulation, especially in Tfh and Treg cells. αTIGIT selectively and strongly suppressed Tfh cells and promoted the suppressive function of Treg cells. b αTIGIT can recover imbalance towards activated T cells by conflicting effects on CD4+ T cells.

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