Fig. 2: Altered inter-regional connectivity underlies the altered hub region connectivity seen in the functional brain networks of 16p11.2 DEL mice. | Communications Biology

Fig. 2: Altered inter-regional connectivity underlies the altered hub region connectivity seen in the functional brain networks of 16p11.2 DEL mice.

From: 16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability

Fig. 2

Chord diagrams showing lost (dark blue) and gained (red) inter-regional connectivity for the a Frontal Association Cortex (FRA), b Dorsal Hippocampus Dentate Gyrus (DH DG) c Insular Cortex (Ins) d Ventromedial Thalamus (VM) in e Vertical Limb of the Diagonal Band of Broca (VDB) and f Horizontal Limb of the Diagonal Band of Broca (HDB) in 16p11.2 DEL mice. Dark blue denotes significantly lost inter-regional connectivity (VIP 95% CI < 1.0 in 16p11.2 DEL and >1.0 in WT; z <−1.96 in DELs v WT) and red denotes significantly gained connectivity (VIP 95% CI > 1.0 16p11.2 DEL and <1.0 WT; z > 1.96 in DELs v WT) in 16p11.2 DEL mice. n = 12 (6 male) mice/genotype. Prefrontal cortex: aPrL Anterior Prelimbic Cortex, FRA Frontal Association Area, DLO Dorsolateral Orbital Cortex, MO Medial Orbital Cortex, LO Lateral Orbital Cortex, mPrL Medial Prelimbic Cortex, IL Infralimbic Cortex, Cg1 Cingulate Cortex; Cortex: Ins Insular Cortex, Piri Piriform Cortex, RSC Retrosplenial Cortex, S1 Somatosensory Cortex; Thalamus: AM Anteromedial Thalamus, TRN Thalamic Reticular Nucleus, aRT Anterior Reticular Thalamus, AV Anteroventral Thalamus, MD Mediodorsal Thalamus, VL Ventrolateral Thalamus, VM Ventromedial Thalamus; Mesolimbic: AcbC Nucleus Accumbens Core, AcbSh Nucleus Accumbens Shell, VTA ventral Tegmental Area; Basal Ganglia: DLST Dorsolateral Striatum, VMST Ventromedial Striatum, GP Globus Pallidus, SNC Substantia Nigra pars Compacta, SNR Substantia Nigra pars Reticulata; Amygdala: BLA Basolateral Amygdala, CeA Central Amygdala, MeA Medial Amygdala; Auditory: IC Inferior Colliculus, MG Medial Geniculate, DB Septum/Diagonal Band of Broca, LS Lateral Septum, MS Medial Septum, HDB Horizontal Limb of DB, VDB Vertical Limb of DB; Hippocampus: DSub Dorsal Subiculum, DH CA1 Dorsal Cornu Ammonis 1, DH CA2 Dorsal Cornu Ammonis 2, DH Mol Dorsal Molecular Layer, DH DG Dorsal Dentate Gyrus, VH CA1 Ventral Cornu Ammonis 1, VH CA3 Ventral Cornu Ammonis 3, VH Mol Ventral Molecular Layer, VH DG Ventral Dentate Gyrus; Multimodal: Hab Habenula, MB Mammillary Body. Brain region abbreviations are also shown in the supplemental material (Supplementary Table 3). Neural systems are colour coded and indicated in the Figure legend.

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