Fig. 5: Male, but not female, 16p11.2 DEL mice show reduced GABAergic gene expression in the reticular thalamic nucleus (TRN) and parietal cortex (ParC). | Communications Biology

Fig. 5: Male, but not female, 16p11.2 DEL mice show reduced GABAergic gene expression in the reticular thalamic nucleus (TRN) and parietal cortex (ParC).

From: 16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability

Fig. 5

Levels of Gad1 mRNA in the a TRN and b ParC are reduced in 16p11.2 DEL male mice. Pvalb mRNA expression is unaltered in the d TRN, but increased in the e ParC of 16p11.2 mice of both sexes. Sst mRNA expression is decreased in the g TRN and unaltered in the h ParC of 16p11.2 DEL male mice. Representative autoradiographs for c Gad1, f Pvalb and j Sst mRNA expression in male mice. i Location of regions analysed: TRN (green) and ParC (purple). Scale bar represents 1000 μm. Box plots show median and interquartile range with “Tukey” whiskers. WT F = wild-type female mice; WT M = wild-type male mice; 16p11 DEL F = 16p11.2 deletion female mice; 16p11.2 DEL M = 16p11.2 deletion male mice. Data were analysed by ANOVA. F and p values are provided in Supplementary Table 1. ***P < 0.001 main effect of genotype (ANOVA). #P < 0.05, ##P < 0.01, Tukey’s post-hoc test vs same sex WT group. n = 12 (8 male) mice/genotype. Arrows in c also show ParC ___location of Gad1 expression.

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