Fig. 5: ScRNA-seq analysis revealed that V-Navo@gel induced an immunostimulatory reprogramming of TME. | Communications Biology

Fig. 5: ScRNA-seq analysis revealed that V-Navo@gel induced an immunostimulatory reprogramming of TME.

From: Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel

Fig. 5

a UMAP plot showing identified cell clusters within T/NK population. b Bubble heatmap showing expression of selected signature genes in each T/NK cluster. Bubble size represents the percentage of expressing cells, colored based on normalized expression levels. c Comparison of T/NK cell clusters between PBS, Virus@gel, and V-Navo@gel treatment. d Quantification of the proportion of each cell-type population based on treatment. e UMAP plot showing identified cell clusters within myeloid-derived population. f Bubble heatmap showing expression of selected signature genes in each myeloid-derived cluster. Bubble size represents the percentage of expressing cells, colored based on normalized expression levels. g Comparison of myeloid-derived cell clusters between PBS, Virus@gel, and V-Navo@gel treatment.

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