Fig. 4: Changes in spleen size parameters.
From: Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
a Dot plot of spleen weight. Note that a reduction in spleen size becomes evident in the FL-KO mice. b Representative images showing HE staining of paraffin-embedded splenic cross sections from mice with the indicated genotypes. c Enlarged views of the selected regions (white boxes) from the images in (b). Note that shrinkage of the white pulp (WP) is obvious in FL-WT and FL-KO mice. d Frequency of WP cells in cross sections. e Calculated numbers of cells residing in WP (left) and red pulp (RP, right) areas in individual spleens. The mean value obtained for GC-WT mice in each group was set to 100%. Dots represent individual animals. Means are shown in the plots. *p < 0.05.
