Fig. 5: Genes downregulated in the spleen after spaceflight.
From: Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
a Venn diagram of downregulated differentially expressed genes (DEGs) in the spleen for the FL-WT vs. GC-WT (green) and FL-KO vs. GC-KO (orange) comparisons. b Gene Ontology (GO) analysis of downregulated DEGs for the FL-WT vs. GC-WT (upper rows) and FL-KO vs. GC-KO (lower rows) comparisons. GO terms related to erythropoiesis are marked with a pink background. The number of genes and the adjusted p values are shown. c Heatmap of the relative expression of downregulated genes in the FL-WT vs. GC-WT or FL-KO vs. GC-KO comparison. The mean value obtained for each gene in GC-WT mice was set to one. Erythroid-related genes are coloured in red. Adjusted P values for the FL-WT vs. GC-WT and FL-KO vs. GC-KO comparisons are shown. d Dot plot of the expression of representative erythroid-related genes. Dots represent individual animals. Means are shown in the plots. *p < 0.05.
