Fig. 4: The interplay between the temporal transcription factor and eLR orchestrates early embryo development. | Communications Biology

Fig. 4: The interplay between the temporal transcription factor and eLR orchestrates early embryo development.

From: TimeTalk uses single-cell RNA-seq datasets to decipher cell-cell communication during early embryo development

Fig. 4

a Heatmap of the interaction scores of all identified 430 eLRs can be grouped into 6 clusters. In the row annotation of the heatmap, the “cluster” column illustrates the classification of the eLR, C1, C2, C3, C4, C5, and C6 columns illustrate the relationship of each eLR to the C1, C2, C3, C4, C5, C6 regulons. In the column annotation of the heatmap, the “Stage” row illustrates the development stage of every single cell, the “Pseudotime” row illustrates the pseudotime, C1, C2, C3, C4, C5, C6 row illustrates the activity of every single cell. b The KEGG analysis of eLRs clustered for each clusters. c–e The cluster 1, cluster 5, and cluster 6 eLR to TF ratio, the signaling network provided by NicheNet can verify the ratio. f The distribution of eLR genes across the regulons of various tTFs. Each row in the figure corresponds to a specific tTF, with the horizontal bar indicating the ratio of eLR genes present in its regulon. g Fgf4-Fgfr1 and Fgf4-Fgfr2 interacted with different tTFs, forming an organized regulatory network.

Back to article page