Fig. 3: Peri-reactivation exposure to a novel OF improves IA-LTM during its reconsolidation by a protein synthesis-dependent process.
From: Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change
Top: experimental design. Figures show latency to step-down from the platform during training (Tr) and test session, expressed as mean ± SEM. R: animals submitted to a reactivation session. NR: animals not submitted to a reactivation session. a: ***p < 0.001 vs Tr and +++ p < 0.001 vs Reactivated, OF (NR), R + (OF-120) and R + (OF + 60), multiple comparisons after Welch’s ANOVA (n = 12–18); W(11, 64.13) = 222.9. b: ***p < 0.001 vs Tr and Veh + (R + EME), multiple comparisons after Welch’s ANOVA (n = 8–10); W(5, 21.7) = 97.57. c: ***p < 0.001 vs Tr and +++p < 0.001 vs R+Veh and OF + (R + AP5), multiple comparisons after Welch’s ANOVA (n = 9–10); W(5, 23.23) = 177.7. d: ***p < 0.001 vs Tr and +++p < 0.001 vs (OF + EME) + R or R + (OF + EME), multiple comparisons after Welch’s ANOVA (n = 14–15; W(5, 29.91) = 64.46 for the left part and n = 11; W(5, 36.75) = 75.66 for the right part).
