Fig. 1: The landscape of EMTCG signature.

a Flowchart of construction of EMTCG signature. Left panel: Venn diagram shown that 103 genes involving only in the positive direction of mesenchymal transition were summarized. Right panel: Identification of 35 EMTCGs by protein-protein interaction network analysis and co-expression analysis. b Multi-omics regulation mechanism including somatic mutation, copy number variation (CNV) or DNA methylation of EMTCGs. Significant correlation (p < 0.0001) was represented on the heat-map. c Univariate Cox regression analysis access Hazard Ratio and prognostic significance of mesenchymal transition activity based on ssGSEA across different cancer types. d Boxplots of mesenchymal transition activity across 24 cancer types, as inferred using ssGSEA based on EMTCGs signature.