Fig. 3: Multi-scale comparison between EMThigh-NOS subtype and EMThigh-AKT subtype. | Communications Biology

Fig. 3: Multi-scale comparison between EMThigh-NOS subtype and EMThigh-AKT subtype.

From: Tumor microenvironment remodeling plus immunotherapy could be used in mesenchymal-like tumor with high tumor residual and drug resistant rate

Fig. 3

a Histological type composition of EMThigh-NOS subtype and EMThigh-AKT subtype. EMThigh-NOS subtype was mainly composited of squamous carcinoma while EMThigh-AKT subtype was mainly composited of adenocarcinoma. b Sample portion composition of EMThigh-NOS subtype and EMThigh-AKT subtype. EMThigh-NOS subtype was mainly composed of recurrent or primary samples while the portion distribution was relatively even in EMThigh-AKT subtype. c WHO grade composition of EMThigh-NOS subtype and EMThigh-AKT subtype. With histological grade progression, mesenchymal transition tumor samples tended to enrich in EMThigh-AKT subtype. d AKT pathway activity was significantly upregulated in EMThigh-AKT subtype. e Gene ontology analysis of EMThigh-NOS subtype and EMThigh-AKT subtype. f Compared to EMThigh-AKT subtype, the mutation rate of TP53 is significantly higher in EMThigh-NOS subtype.

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