Fig. 4: Effect of SH3RF2 depletion on DDP-induced DNA damage in OC in vitro.
From: SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
DDP-resistant OC cells with or without depletion of SH3RF2 were exposed to DDP (A2780/DDP: 30 μM; SKOV3/DDP: 22 μM) for 48 h. n = 3. a Comet assays of DDP-resistant OC cells (Scale bars, 100 μm). n = 3. b Immunofluorescence of γH2AX in DDP-resistant OC cells (Scale bars, 25 μm). n = 3. c Western blots of lysates from DDP-resistant OC cells stained for γH2AX. n = 3. Data are expressed as the mean ± SD. The p values were determined by one-way ANOVA. NS, no significance.
