Fig. 5: Effect of SH3RF2 depletion on DDP resistance in the OC xenograft model.
From: SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
The OC xenograft model was established by subcutaneous injection of DDP-resistant OC cells (1 × 106 cells per mice). a, b Tumor volumes were quantified every 3 days (p < 0.01 or p < 0.05 vs. the shNC/DDP+shNC/shSH3RF2 group) and the tumors were weighed 21 days after injection. n = 6. c–e IHC staining of SH3RF2, Ki67, cleaved caspase 3, and γH2AX in the tumor tissues (Scale bars, 50 μm). n = 6. Data are expressed as the mean ± SD. The p values were determined by Kruskal-Wallis test or two-way ANOVA. NS, no significance.
