Fig. 7: Effect of SH3RF2 depletion on AP-1 signaling in DDP-resistant OC cells.
From: SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
a To determine the AP-1-dependent transcriptional activities, DDP-resistant OC cells were co-transfected with pAP1-Ta-luc and pRL-TK plasmids. Luciferase activity assays were performed at 48 h after cell transfection. n = 3. b RT-qPCR analysis of AP-1 downstream genes XIAP and MYC in DDP-resistant OC cells with stable depletion of SH3RF2. n = 3. c, d RT-qPCR analysis of AP-1 downstream genes XIAP and MYC in the xenograft tumor tissues generated by DDP-resistant OC cells with stable depletion of SH3RF2. n = 6. Data are expressed as the mean ± SD. The p values were determined by one-way or two-way ANOVA.
