Fig. 3: Comparison of associations of protein biomarkers with 1-SD higher BMI, BF%, WC and WHR in conventional vs. genetic analyses in CKB and CKB vs. UKB genetic analyses. | Communications Biology

Fig. 3: Comparison of associations of protein biomarkers with 1-SD higher BMI, BF%, WC and WHR in conventional vs. genetic analyses in CKB and CKB vs. UKB genetic analyses.

From: Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels

Fig. 3

Figures (a–d) represent the comparison of the associations of BMI, BF%, WC, and WHR, respectively, with protein biomarkers, either between CKB conventional and genetic analyses or between CKB and UKB genetic analyses. The x-axis and y-axis represent the effect size of the associations between the adiposity traits and the protein biomarkers. Black dots denote Olink batch 1 FDR-corrected associations, red dots denote batch 2 FDR-corrected associations, while grey dots denote non-significant associations, and grey lines indicate the 95% confidence intervals.  In CKB, analyses were adjusted for age, age2, sex, study area, fasting time, ambient temperature, ascertainment status, and the first 11 PCs (for genetic analyses only). In UKB, analyses were adjusted for age, age2, sex, assessment centre, fasting time, plate ID, and the first 40 PCs (for genetic analyses only). BF% body fat percentage, BMI body mass index, CKB China Kadoorie Biobank, SD standard deviation, UKB UK Biobank, WC waist circumference, WHR waist-to-hip ratio.

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