Fig. 1: I/R leads to vascular alterations in the inner retinal layers. | Communications Biology

Fig. 1: I/R leads to vascular alterations in the inner retinal layers.

From: Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion

Fig. 1

A Fundus images and OCTA images of the same eyeball from one mouse before ligation (Sham), after ligation (BCAL) and reperfusion 7 days, respectively. Left: Fundus images of retinal vessels; Right: Angiogram of retinal scans obtained through OCTA showing retinal NFL + GCL, IPL and OPL vessels. B Retinal tomography images from OCTA (scale bar: horizontal, 250 µm; vertical: 150 µm), with a magnified image on the right (scale bar: horizontal, 50 µm; vertical: 50 µm). C Percentage of bright vessels of NFL + GCL, IPL, OPL and whole retina in the sham (n = 11 eyes, n = 8 mice), Rep1d (n = 9 eyes, n = 5 mice), Rep3d (n = 6 eyes, n = 4 mice) and Rep7d (n = 14 eyes, n = 10 mice) mice. *p < 0.05, ***p < 0.001. D Thicknesses of the inner retina (NFL + GCL + IPL), INL, OPL, and ONL in the sham (n = 14 eyes, n = 7 mice), Rep1d (n = 10 eyes, n = 5 mice), Rep3d (n = 6 eyes, n = 4 mice) and Rep7d (n = 12 eyes, n = 9 mice). Data were displayed as mean ± SEM.

Back to article page