Roadmap

Metabolic dysfunction-associated steatohepatitis (MASH), a primary cause of chronic liver disease (CLD), often leads to advanced CLD stages such as cirrhosis. This Roadmap summarizes the current landscape and challenges of MASH-related compensated cirrhosis clinical trials and explores a way forward for future studies.

Single-cell profiling studies of the human gastrointestinal tract are increasing, offering an excellent opportunity to generate the first Human Gut Cell Atlas. This Roadmap presents a structured direction towards this goal and provides a detailed overview of the major challenges.

Currently, there is no cure for hepatitis B virus (HBV) infection, which can lead to chronic liver disease and liver cancer, and only a few biomarkers are available. This Roadmap provides an overview of HBV serum biomarkers and their challenges.

In this Roadmap, Furth, Sethupathy and colleagues discuss advances in our understanding of the mechanisms and treatments of fibrolamellar carcinoma, a rare hepatic cancer that primarily occurs in adolescents and young adults. Recommendations for future progress in research and clinical trials are proposed.

Coeliac disease is a serious condition and a model disease that can shed light into the mechanisms that underlie autoimmunity and chronic inflammation. This Roadmap summarizes key advances in coeliac disease and provides recommendations from a consensus workshop to address the gaps and opportunities in the pathogenesis, diagnosis and management of coeliac disease, providing a path forward.