Fig. 9
Differential membrane architecture alteration in the presence of α-synuclein fibrils derived oligomeric conformations. 3D atomic force microscopic images (60 × 60 µm) of SH-SY5Y cells. A magnified 3D surface (10 × 10 µm). a, c Fibrils treated. b, d Fibrils derived α-synuclein oligomer treated. The membrane damage is marked with a white circle. Each image is presented with a height scale. Distinct pore-like features and neurites degeneration were clearly seen on neuroblastoma SH-SY5Y cells treated with fibrils derived α-synuclein oligomers. The neurite degeneration is absent in fibrils treated cells. Certain membrane perturbations were also seen with fibril treated cells
