Fig. 3: Mutations observed in yeast IVIEWGA experiments.
a Base transition. Classification of mutation based on base transition type for 1286 SNV mutations obtained via compound selection and absence of compound selection105. b Classification of the most common mutation types in the dataset and their occurrence in essential vs. nonessential genes. Essentiality data were imported from the Saccharomyces Genome Deletion Project database and proportion of essential vs. nonessential genes that contained missense, synonymous, frameshift, and stop gained mutations were calculated. c Mutation type. Variant classes for 1405 mutations (INDELs and SNVs supplied from Supplementary Data 4) obtained via compound selection versus a mutation dataset from non-compound selection conditions105. d Circos plot. Circos plot of SNVs (blue), INDELs (orange), and CNVs (cyan) identified through resistance generation, generated with BioCircos R package106. e–g Intergenic mutations. Plot locating each coding region mutation onto the gene (gray) and intergenic mutation onto the chromosome (orange) based on the calculated distance. Mutations were mapped to their corresponding genomic ___location using S. cerevisiae S288C genome version R64-2-1. Intergenic mutations are located at no more than 500 bp away from the start/end of the gene.
