Fig. 6: CVRF associations with volume and MTsat in white matter tracts and their grey matter seed and target regions (n = 1104).

Standardised βs are marked with an asterisk for significant associations (FDR-corrected p < 0.05). a Constituent sub-regions of the seed and target of each tract. b GM and WM associations with hypertension. c, d GM and WM associations with high BMI in c male and d female participants. A/PCG anterior/posterior cingulate gyrus, AF arcuate fasciculus, Amyg amygdala, AnG angular gyrus, A/L/M/POrG anterior/lateral/middle/posterior orbital gyrus, BMI body mass index, Calc calcarine cortex, CC corpus callosum (1 = rostrum, 2 = genu, 3 = rostral body, 4 = anterior midbody, 5 = posterior midbody, 6 = isthmus, 7 = splenium), CG cingulum bundle, CST cortico-spinal tract, Ent. area entorhinal area, FRP frontal pole, FX fornix, GM grey matter, GRe gyrus rectus, Hippoc hippocampus, IFO inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, I/M/SOG inferior/middle/superior occipital gyrus, I/M/S/TTG inferior/middle/superior/transverse temporal gyrus, LiG lingual gyrus, MFC medial frontal cortex, M/SFG middle/superior frontal gyrus, MLF middle longitudinal fasciculus, (M)Po/PrG post/precentral gyrus (medial segment), MTsat magnetization transfer saturation, Op/Or/TrIFG opercular/orbital/triangular part of inferior frontal gyrus, OCP occipital pole, OFuG occipital fusiform gyrus, OR optic radiation, PHG parahippocampal gyrus, PO parietal operculum, Precun precuneus, SCA subcallosal area, SLF superior longitudinal fasciculus, SMC supplementary motor cortex, SMG supramarginal gyrus, SPL superior parietal lobule, TMP temporal pole, UF uncinate fasciculus, Ventral DC ventral diencephalon, WM white matter.