Fig. 3: Glutamate metabolism in TVM cells was more active in the ART group than the TN group. | Communications Biology

Fig. 3: Glutamate metabolism in TVM cells was more active in the ART group than the TN group.

From: Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy

Fig. 3

a Two-dimensional UMAP projection of 48654 cells was conducted by unsupervised clustering and the distribution of characteristic gene expression in each cluster. b UMAP projection of CD8+ T cell metabolic clusters. c Heatmap of glutamate metabolism genes and metabolism-related genes screened from DEGs. d Overlapping UMAP of CD8+ T cells in TN, ART, and HCs groups. e Violin plot comparing the score of glutamate-related metabolic pathways between TN, ART, and HC groups in TVM cells. f Violin plot comparing the expression of glutamate metabolism genes between TN, ART, and HC groups in TVM cells. g Summary of glutamate metabolism genes upregulated by the ART group.

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