Fig. 6: The release of profibrotic cytokines was effectively reduced in UUO and FA kidneys after inhibiting ACSL4. | Communications Biology

Fig. 6: The release of profibrotic cytokines was effectively reduced in UUO and FA kidneys after inhibiting ACSL4.

From: Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease

Fig. 6

a, b Western-blot analyzing the expression of profibrotic cytokines TGF-β, p-Smad2 and p-Smad3 in UUO-and FA-treated kidney samples. The relative abundance of the indicated protein expression was normalized by GAPDH (right panel). n = 5 mice. c Profibrotic cytokines TGF-β, CΤGF, FGF2 and PDGFB mRNA detected by RT-qPCR analysis in UUO and FA-treated mice. n = 5 mice. Representative images from more than three independent experiments are shown above. Data are presented as mean ± SEM. *P < 0.05, ns means no statistical significance.

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