Fig. 3: The predicted eLRs can be validated through extensive in-silico analyses. | Communications Biology

Fig. 3: The predicted eLRs can be validated through extensive in-silico analyses.

From: TimeTalk uses single-cell RNA-seq datasets to decipher cell-cell communication during early embryo development

Fig. 3

a The predicted eLRs; each dot represents an eLR. Previously reported eLR pairs were highlighted. b The enrichment ratio of essential genes in the sets of all protein-coding genes (all), ligands and receptors (LRs), and eLRs. c The enrichment ratio of housekeeping genes in all protein-coding genes (all), ligands and receptors (LRs), and eLRs. d The enrichment ratio of ZGA genes in the sets of all protein-coding genes (all), ligands and receptors (LRs), and eLRs. We used the hypergeometric test to assess the results’ significance in (b–d). e Heatmap of the interaction scores of some eLRs that were down-regulated by the ZGA inhibition, the ZGA-inhibited RNA-seq data downloaded from GSE71434.

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