Fig. 3: TMOD1 localizes correctly in patient cardiomyocytes.
From: Recessive TMOD1 mutation causes childhood cardiomyopathy
a Sarcomeric structure in Patient 1 and three control iPSC-cardiomyocytes (Scale bars = 50 µm and 10 µm). cTnT: cardiac troponin T (green) and alpha-actinin (red): component of the Z-disk. b TMOD1 (green) localization in the patient and control iPSC-cardiomyocytes (Scale bars = 25 µm and 5 µm). Phalloidin (red) staining was used for visualization of filamentous actin. The regions in white boxes in left panels of (a) and (b) are shown at higher magnification in the right panels of (a) and (b). Note that the sporadic appearance of TMOD1 in both control and patient samples as a broader band (doublet) is linked to the precise relaxation of the sarcomere and/or the angle of the myofibril that is being photographed.
