Fig. 1: Frequencies of CD19+ B cells differ between blood and lung compartments. | Communications Biology

Fig. 1: Frequencies of CD19+ B cells differ between blood and lung compartments.

From: B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

Fig. 1

a Representative flow plots identifying CD19+ B cells from peripheral blood mononuclear cells (PBMC) and resected lung tissue. b B cell frequencies in the blood were compared for a set of healthy controls (HC, n = 6), patients with latent TB (LTBI, n = 10) or active TB (ATBI, n = 15), demonstrating reduced circulating B cells in active TB. c B cell frequencies were compared for lung tissue versus matched blood of cancer control patients (in cyan, n = 8) and patients with TB (in red, n = 60). B cell numbers were increased in the lung compared to the blood in patients with TB, and also relative to cancer control lung tissue. d In contrast, comparative frequencies of CD3+ T cells between lung tissue and matched blood of patients with TB showed no significant difference. Statistical analyses were performed using the Mann–Whitney test between unmatched samples and the Wilcoxon test for matched/paired samples. P values are denoted by ** <0.01.

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