Fig. 5: Immune landscape in the BM in the acute phase after blast.

The BM cells collected from control mice or mice experienced an explosion were used for mass cytometry-based analysis. a viSNE maps colored by 13 cell populations of the BM CD45⁺ cells after clustering. b–e Dot plots (n = 30) showing the Pearson correlation coefficients for relationships between the proportions of the indicated cell populations in the BM CD45⁺ cells and the LI score (left). Bar plots showing the frequencies of indicated populations in the BM CD45⁺ cells of control mice (n = 10) and blast-treated mice 1.6 (n = 10) or 2.2 (n = 10) m from the explosion site (right). f Bar plots showing the frequencies of indicated populations in the BM CD45⁺ cells of control mice and blast-treated mice 1.6 or 2.2 m from the explosion site. g Bar plots showing the normalized expression of significantly changed intracellular proteins in the indicated BM CD45⁺ cell populations. h Radar plots showing the average frequencies of the indicated populations in the lung, SP, BM or PWB cells of control mice and blast-treated mice 1.6 or 2.2 m from the blast site. i PCA and corresponding vector plot of contributions for immune cell frequencies in the lung and LI score from control mice and blast-treated mice 1.6 or 2.2 m from the blast site. Error bar, mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.