Fig. 7: Immune landscape in peripheral blood during blast injury repair.

The peripheral blood collected from mice experienced an explosion for the indicated days was used for mass cytometry-based single-cell analysis. a Stacked bar plot showing the average frequencies of the indicated cell populations in the peripheral blood of controls and mouse models killed on Day(s) 1, 3, and 7 post-explosion exposure. b Dot plots (n = 37) showing the Pearson correlation coefficients for relationships between the proportions of the indicated cell populations in the PWB cells and the lung injury (LI) score (left). Bar plots showing the frequencies of indicated populations in the PWB of controls (day 0, n = 9) and mouse models killed on day(s) 1 (n = 8), 3 (n = 10), and 7 (n = 10) post-explosion exposure (right). c and d Bar plots showing the frequencies of indicated populations in the PWB of controls and mouse models killed on day(s) 1, 3, and 7 post-explosion exposure. e Bar plots showing the normalized expression of significantly changed intracellular proteins in the indicated PWB cell populations. f SPADE tree describing 50 minor peripheral blood T cell clusters of one representative mouse colored by the median expression of the indicated markers. g and h Bar plots showing the frequencies of the indicated T cell SPADE cluster in peripheral blood T cells of controls and mouse models killed on day(s) 1, 3, and 7 post-explosion exposure. Error bar, mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.